ADRBK2 - Beta-adrenergic receptor kinase 2 - human protein (Function)
 
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ADRBK2 »  Beta-adrenergic receptor kinase 2   [ EC 2.7.11.15 ]  (Beta-ARK-2)
 
Protein also known as:  G-protein-coupled receptor kinase 3.
Gene name:  ADRBK2
Entry whose protein(s) existence is based on evidence at protein level
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1 35 1
GENE REF ISO

Function

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Overview 
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Beta-adrenergic receptor kinase activitydefinition[GO:0047696]  
  • IEAEC 2 GO
G-protein coupled receptor kinase activitydefinition[GO:0004703] silver  
  • IEAOrtholog Compara
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
GO biological process 
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Receptor internalizationdefinition[GO:0031623]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.15: ATP + [beta-adrenergic receptor] ADP + [beta-adrenergic receptor] phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+157  
Endocytosis  hsa04144+157  
Glutamatergic synapse  hsa04724+157  
Olfactory transduction  hsa04740+157  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Beta_adrenergic_receptor_kinase-2
GenomeRNAi: 157
PRO: PR:P35626
Chemistry
GuidetoPHARMACOLOGY: 1467