FUS - RNA-binding protein FUS - human protein (Function)
 
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FUS »  RNA-binding protein FUS
 
Protein also known as:  Translocated in liposarcoma protein.
Gene name:  FUS
Family name: RRM TET
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.  
1
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
RNA bindingdefinition[GO:0003723]  
1
  • PINC
Transcription coactivator activitydefinition[GO:0003713] silver  
1
  • CACAO
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Regulation of nucleic acid-templated transcriptiondefinition[GO:1903506]  
1
  • GOC
Pathways 
According to Reactome, this protein belongs to the following pathway:
mRNA Splicing - Major Pathway  REACT_467  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FUS
GenomeRNAi: 2521
PRO: PR:P35637