ATP7B - Copper-transporting ATPase 2 - human protein (Function)
 
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ATP7B »  Copper-transporting ATPase 2   [ EC 3.6.3.54 ]
 
Protein also known as:  Wilson disease-associated protein. Cleaved into:  WND/140 kDa.
Gene name:  ATP7B
Entry whose protein(s) existence is based on evidence at protein level
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1 232 4
GENE REF ISO

Function

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Overview 
Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.5.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
2
  • IDAUniProtKB
  • IDAHGNC
Copper ion bindingdefinition[GO:0005507]  
2
  • IDAHGNC
  • IDAUniProtKB
Copper-exporting ATPase activitydefinition[GO:0004008]  
2
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Cellular copper ion homeostasisdefinition[GO:0006878]  
1
  • TASUniProtKB
Cellular zinc ion homeostasisdefinition[GO:0006882] silver  
  • IEAOrtholog Compara
Copper ion exportdefinition[GO:0060003] silver  
  • IEAOrtholog Compara
Copper ion importdefinition[GO:0015677]  
1
  • IDAUniProtKB
Copper ion transportdefinition[GO:0006825]  
1
  • IGIUniProtKB
Intracellular copper ion transportdefinition[GO:0015680] silver  
  • IEAOrtholog Compara
Lactationdefinition[GO:0007595] silver  
  • IEAOrtholog Compara
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Response to copper iondefinition[GO:0046688]  
3
  • IDAUniProtKB
Sequestering of calcium iondefinition[GO:0051208]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.54: ATP + H(2)O + Cu(+)(Side 1) ADP + phosphate + Cu(+)(Side 2).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Ion transport by P-type ATPases  REACT_25149  
 

Keywords

Biological process 
Copper transport  definition   [KW-0187]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Wilson_disease_protein
GenomeRNAi: 540
PRO: PR:P35670