MYH11 - Myosin-11 - human protein (Function)
 
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Protein
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MYH11 »  Myosin-11
 
Protein also known as:  Myosin heavy chain, smooth muscle isoform.
Gene name:  MYH11
Entry whose protein(s) existence is based on evidence at protein level
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1 68 4
GENE REF ISO

Function

 show evidences
Overview 
Muscle contraction.  
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015] silver  
  • IEAInterPro 2 GO
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Motor activitydefinition[GO:0003774] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Structural constituent of muscledefinition[GO:0008307]  
1
  • IMPUniProtKB
GO biological process 
Cardiac muscle fiber developmentdefinition[GO:0048739]  
1
  • IMPUniProtKB
Elastic fiber assemblydefinition[GO:0048251]  
1
  • IMPUniProtKB
Metabolic processdefinition[GO:0008152]  
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
Skeletal muscle myosin thick filament assemblydefinition[GO:0030241]  
  • ISSOrtholog Curator
Smooth muscle contractiondefinition[GO:0006939]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Tight junction  hsa04530+4629  
Vascular smooth muscle contraction  hsa04270+4629  
Viral myocarditis  hsa05416+4629  
According to Reactome, this protein belongs to the following pathways:
Sema4D induced cell migration and growth-cone collapse  REACT_19277  
Smooth Muscle Contraction  REACT_20558  
 

Keywords

Molecular function 
Motor protein  definition   [KW-0505]
Muscle protein  definition   [KW-0514]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYH11
GenomeRNAi: 4629
PRO: PR:P35749