AHR - Aryl hydrocarbon receptor - human protein (Function)
 
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AHR »  Aryl hydrocarbon receptor  (AhR)
 
Protein also known as:  Class E basic helix-loop-helix protein 76 (bHLHe76).
Gene name:  AHR
Entry whose protein(s) existence is based on evidence at protein level
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1 261 1
GENE REF ISO

Function

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Overview 
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • TASDFLAT
E-box bindingdefinition[GO:0070888]  
  • ISSOrtholog Curator
Enhancer bindingdefinition[GO:0035326]  
1
  • IDAMGI
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
Protein dimerization activitydefinition[GO:0046983]  
1
  • TASDFLAT
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • TASDFLAT
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAMGI
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDADFLAT
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Blood vessel developmentdefinition[GO:0001568]  
1
  • NASDFLAT
Cell cycledefinition[GO:0007049]  
1
  • TASUniProtKB
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • IDAGOC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Positive regulation of RNA polymerase II transcriptional preinitiation complex assemblydefinition[GO:0045899] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Prostate gland developmentdefinition[GO:0030850] silver  
  • IEAOrtholog Compara
Regulation of B cell proliferationdefinition[GO:0030888]  
1
  • IDADFLAT
Regulation of gene expressiondefinition[GO:0010468]  
1
  • IDADFLAT
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • IDADFLAT
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • IDAUniProtKB
Response to xenobiotic stimulusdefinition[GO:0009410]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • TASDFLAT
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Aryl_hydrocarbon_receptor
GenomeRNAi: 196
PRO: PR:P35869