AHR - Aryl hydrocarbon receptor - human protein (Function)
 
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AHR »  Aryl hydrocarbon receptor  (AhR)
 
Protein also known as:  Class E basic helix-loop-helix protein 76 (bHLHe76).
Gene name:  AHR
Entry whose protein(s) existence is based on evidence at protein level
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1 272 1
GENE REF ISO

Function

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Overview 
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.  
3
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • DFLAT
E-box bindingdefinition[GO:0070888]  
1
  • Ortholog Curator
Enhancer bindingdefinition[GO:0035326]  
1
  • MGI
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • BHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • BHF-UCL
Protein dimerization activitydefinition[GO:0046983]  
1
  • DFLAT
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • DFLAT
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • MGI
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • BHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • DFLAT
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Blood vessel developmentdefinition[GO:0001568]  
1
  • DFLAT
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Circadian regulation of gene expressiondefinition[GO:0032922]  
1
  • Ortholog Curator
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • GOC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • Ortholog Curator
Positive regulation of RNA polymerase II transcriptional preinitiation complex assemblydefinition[GO:0045899] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • RefGenome
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Prostate gland developmentdefinition[GO:0030850] silver  
1
  • Ortholog Compara
Regulation of B cell proliferationdefinition[GO:0030888]  
1
  • DFLAT
Regulation of gene expressiondefinition[GO:0010468]  
1
  • DFLAT
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • DFLAT
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Response to toxic substancedefinition[GO:0009636]  
1
  • UniProtKB
Response to xenobiotic stimulusdefinition[GO:0009410]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • UniProtKB
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • DFLAT
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Aryl_hydrocarbon_receptor
GenomeRNAi: 196
PRO: PR:P35869