AHR - Aryl hydrocarbon receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
AHR »  Aryl hydrocarbon receptor  (AhR)
 
Protein also known as:  Class E basic helix-loop-helix protein 76 (bHLHe76).
Gene name:  AHR
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 238 1
GENE REF ISO

Function

 show evidences
Overview 
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • TASDFLAT
Hsp90 protein bindingdefinition[GO:0051879]  
1
  • IDABHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
Protein dimerization activitydefinition[GO:0046983]  
1
  • TASDFLAT
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • TASDFLAT
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAMGI
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDADFLAT
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Blood vessel developmentdefinition[GO:0001568]  
1
  • NASDFLAT
Cell cycledefinition[GO:0007049]  
1
  • TASUniProtKB
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • IDAGOC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of RNA polymerase II transcriptional preinitiation complex assemblydefinition[GO:0045899] silver  
  • IEAOrtholog Compara
Prostate gland developmentdefinition[GO:0030850] silver  
  • IEAOrtholog Compara
Regulation of B cell proliferationdefinition[GO:0030888]  
1
  • IDADFLAT
Regulation of gene expressiondefinition[GO:0010468]  
1
  • IDADFLAT
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • IDADFLAT
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • IDAUniProtKB
Response to xenobiotic stimulusdefinition[GO:0009410]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • TASDFLAT
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Aryl_hydrocarbon_receptor
GenomeRNAi: 196
PRO: PR:P35869