SLC16A2 - Monocarboxylate transporter 8 - human protein (Function)
 
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Protein
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References

 
SLC16A2 »  Monocarboxylate transporter 8  (MCT 8)
 
Protein also known as:  X-linked PEST-containing transporter.
Gene name:  SLC16A2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity).  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the major facilitator superfamily (mfs)  2.A.1.13.10  
GO molecular function 
Monocarboxylic acid transmembrane transporter activitydefinition[GO:0008028]  
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  • PINC
Symporter activitydefinition[GO:0015293]  
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  • UniProtKB KW
Thyroid hormone transmembrane transporter activitydefinition[GO:0015349]  
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  • RefGenome
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Ion transmembrane transportdefinition[GO:0034220]  
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  • RefGenome
Monocarboxylic acid transportdefinition[GO:0015718]  
1
  • PINC
Thyroid hormone transportdefinition[GO:0070327]  
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  • RefGenome
Transportdefinition[GO:0006810]  
1
  • PINC
Note 
Abnormal brain development associated with MCT8 deficiency may be the consequence of either decreased or increased intracellular T3 concentrations.  
1
  • UniProtKB
 

Keywords

Biological process 
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC16A2
GenomeRNAi: 6567
PRO: PR:P36021