GJA5 - Gap junction alpha-5 protein - human protein (Function)
 
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Protein
Gene
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GJA5 »  Gap junction alpha-5 protein
 
Protein also known as:  Connexin-40 (Cx40).
Gene name:  GJA5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  
1
  • UniProtKB
GO molecular function 
Connexin bindingdefinition[GO:0071253] silver  
1
  • Ortholog Compara
Gap junction channel activity involved in AV node cell-bundle of His cell electrical couplingdefinition[GO:0086077]  
1
  • BHF-UCL
Gap junction channel activity involved in cardiac conduction electrical couplingdefinition[GO:0086075]  
2
  • BHF-UCL
Gap junction hemi-channel activitydefinition[GO:0055077]  
1
  • BHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB
Artery morphogenesisdefinition[GO:0048844]  
1
  • Ortholog Curator
Atrial septum developmentdefinition[GO:0003283]  
1
  • BHF-UCL
Atrial septum morphogenesisdefinition[GO:0060413] silver  
1
  • Ortholog Compara
Atrial ventricular junction remodelingdefinition[GO:0003294] silver  
1
  • Ortholog Compara
AV node cell to bundle of His cell communication by electrical couplingdefinition[GO:0086053]  
1
  • BHF-UCL
Bundle of His cell to Purkinje myocyte communication by electrical couplingdefinition[GO:0086054]  
1
  • BHF-UCL
Cardiac conduction system developmentdefinition[GO:0003161] silver  
1
  • Ortholog Compara
Cell communication by chemical couplingdefinition[GO:0010643] silver  
1
  • Ortholog Compara
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
2
  • BHF-UCL
Embryonic heart tube developmentdefinition[GO:0035050] silver  
1
  • Ortholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
1
  • Ortholog Compara
Endothelium developmentdefinition[GO:0003158] silver  
1
  • Ortholog Compara
Foramen ovale closuredefinition[GO:0035922] silver  
1
  • Ortholog Compara
Gap junction assemblydefinition[GO:0016264]  
2
  • BHF-UCL
Mitral valve developmentdefinition[GO:0003174]  
1
  • BHF-UCL
Negative regulation of blood pressuredefinition[GO:0045776] silver  
1
  • Ortholog Compara
Negative regulation of glomerular filtrationdefinition[GO:0003105] silver  
1
  • Ortholog Compara
Outflow tract morphogenesisdefinition[GO:0003151]  
1
  • BHF-UCL
Positive regulation of cell communication by chemical couplingdefinition[GO:0010652] silver  
1
  • Ortholog Compara
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
1
  • Ortholog Compara
Positive regulation of vasodilationdefinition[GO:0045909] silver  
1
  • Ortholog Compara
Potassium ion transportdefinition[GO:0006813] silver  
1
  • Ortholog Compara
Protein oligomerizationdefinition[GO:0051259] silver  
1
  • Ortholog Compara
Pulmonary valve formationdefinition[GO:0003193]  
1
  • BHF-UCL
Regulation of atrial cardiac muscle cell action potentialdefinition[GO:0098910]  
1
  • BHF-UCL
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371]  
2
  • BHF-UCL
Regulation of AV node cell action potentialdefinition[GO:0098904]  
1
  • BHF-UCL
Regulation of bundle of His cell action potentialdefinition[GO:0098905]  
1
  • BHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
3
  • BHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091] silver  
1
  • Ortholog Compara
Regulation of membrane depolarization during cardiac muscle cell action potentialdefinition[GO:1900825] silver  
1
  • Ortholog Compara
Regulation of Purkinje myocyte action potentialdefinition[GO:0098906]  
1
  • BHF-UCL
Regulation of renin secretion into blood streamdefinition[GO:1900133] silver  
1
  • Ortholog Compara
Regulation of ventricular cardiac muscle cell membrane depolarizationdefinition[GO:0060373] silver  
1
  • Ortholog Compara
Regulation of ventricular cardiac muscle cell membrane repolarizationdefinition[GO:0060307] silver  
1
  • Ortholog Compara
SA node cell action potentialdefinition[GO:0086015] silver  
1
  • Ortholog Compara
Septum primum developmentdefinition[GO:0003284] silver  
1
  • Ortholog Compara
Skeletal system developmentdefinition[GO:0001501] silver  
1
  • Ortholog Compara
Transmembrane transportdefinition[GO:0055085] silver  
1
  • Ortholog Compara
Vasomotiondefinition[GO:1990029] silver  
1
  • Ortholog Compara
Ventricular cardiac muscle cell action potentialdefinition[GO:0086005] silver  
1
  • Ortholog Compara
Ventricular septum developmentdefinition[GO:0003281]  
1
  • BHF-UCL
Ventricular septum morphogenesisdefinition[GO:0060412] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Gap junction assembly  REACT_9509  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GJA5
GenomeRNAi: 2702
PRO: PR:P36382
Chemistry
GuidetoPHARMACOLOGY: 726