GJA5 - Gap junction alpha-5 protein - human protein (Function)
 
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GJA5 »  Gap junction alpha-5 protein
 
Protein also known as:  Connexin-40 (Cx40).
Gene name:  GJA5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.  
1
  • UniProtKB
GO molecular function 
Gap junction channel activity involved in AV node cell-bundle of His cell electrical couplingdefinition[GO:0086077]  
1
  • BHF-UCL
Gap junction channel activity involved in cardiac conduction electrical couplingdefinition[GO:0086075]  
2
  • BHF-UCL
Gap junction hemi-channel activitydefinition[GO:0055077]  
1
  • BHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB
Artery morphogenesisdefinition[GO:0048844]  
1
  • Ortholog Curator
Atrial cardiac muscle cell action potentialdefinition[GO:0086014]  
1
  • BHF-UCL
Atrial septum developmentdefinition[GO:0003283]  
1
  • BHF-UCL
AV node cell to bundle of His cell communication by electrical couplingdefinition[GO:0086053]  
1
  • BHF-UCL
Bundle of His cell to Purkinje myocyte communicationdefinition[GO:0086069]  
1
  • BHF-UCL
Cell communication by electrical coupling involved in cardiac conductiondefinition[GO:0086064]  
2
  • BHF-UCL
Gap junction assemblydefinition[GO:0016264]  
2
  • BHF-UCL
Mitral valve developmentdefinition[GO:0003174]  
1
  • BHF-UCL
Outflow tract morphogenesisdefinition[GO:0003151]  
1
  • BHF-UCL
Pulmonary valve formationdefinition[GO:0003193]  
1
  • BHF-UCL
Regulation of atrial cardiac muscle cell membrane depolarizationdefinition[GO:0060371]  
2
  • BHF-UCL
Regulation of cardiac muscle contractiondefinition[GO:0055117]  
3
  • BHF-UCL
Transmembrane transportdefinition[GO:0055085]  
1
  • GOC
Ventricular septum developmentdefinition[GO:0003281]  
1
  • BHF-UCL
Pathways 
According to Reactome, this protein belongs to the following pathway:
Gap junction assembly  REACT_9509  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GJA5
GenomeRNAi: 2702
PRO: PR:P36382
Chemistry
GuidetoPHARMACOLOGY: 726