MAP2K2 - Dual specificity mitogen-activated protein kinase kinase 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
MAP2K2 »  Dual specificity mitogen-activated protein kinase kinase 2   [ EC 2.7.12.2 ]  (MAPKK 2)
 
Protein also known as:  ERK activator kinase 2.
Gene name:  MAP2K2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 139 1
GENE REF ISO

Function

 show evidences
Overview 
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
1
  • Ortholog Compara
MAP kinase kinase activitydefinition[GO:0004708]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
PDZ domain bindingdefinition[GO:0030165]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
Protein complex scaffolddefinition[GO:0032947] silver  
1
  • Ortholog Compara
Protein serine/threonine kinase activator activitydefinition[GO:0043539]  
1
  • UniProtKB
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
1
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB KW
Scaffold protein bindingdefinition[GO:0097110]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • UniProtKB
Epithelial cell proliferation involved in lung morphogenesisdefinition[GO:0060502] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • UniProtKB
Peptidyl-serine autophosphorylationdefinition[GO:0036289]  
1
  • UniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB KW
Positive regulation of axonogenesisdefinition[GO:0050772] silver  
1
  • Ortholog Compara
Positive regulation of cell motilitydefinition[GO:2000147] silver  
1
  • Ortholog Compara
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902]  
1
  • UniProtKB
Regulation of axon regenerationdefinition[GO:0048679] silver  
1
  • Ortholog Compara
Regulation of early endosome to late endosome transportdefinition[GO:2000641]  
1
  • UniProtKB
Regulation of Golgi inheritancedefinition[GO:0090170]  
1
  • UniProtKB
Regulation of stress-activated MAPK cascadedefinition[GO:0032872]  
1
  • UniProtKB
Trachea formationdefinition[GO:0060440] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.2: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+5605  
B cell receptor signaling pathway  hsa04662+5605  
Bladder cancer  hsa05219+5605  
Chronic myeloid leukemia  hsa05220+5605  
Endometrial cancer  hsa05213+5605  
ErbB signaling pathway  hsa04012+5605  
Fc epsilon RI signaling pathway  hsa04664+5605  
Gap junction  hsa04540+5605  
Glioma  hsa05214+5605  
GnRH signaling pathway  hsa04912+5605  
Influenza A  hsa05164+5605  
Insulin signaling pathway  hsa04910+5605  
Long-term depression  hsa04730+5605  
Long-term potentiation  hsa04720+5605  
MAPK signaling pathway  hsa04010+5605  
Melanogenesis  hsa04916+5605  
Melanoma  hsa05218+5605  
Natural killer cell mediated cytotoxicity  hsa04650+5605  
Neurotrophin signaling pathway  hsa04722+5605  
Non-small cell lung cancer  hsa05223+5605  
Pathways in cancer  hsa05200+5605  
Prion diseases  hsa05020+5605  
Prostate cancer  hsa05215+5605  
Regulation of actin cytoskeleton  hsa04810+5605  
Renal cell carcinoma  hsa05211+5605  
T cell receptor signaling pathway  hsa04660+5605  
Thyroid cancer  hsa05216+5605  
Toll-like receptor signaling pathway  hsa04620+5605  
Vascular smooth muscle contraction  hsa04270+5605  
VEGF signaling pathway  hsa04370+5605  
According to Reactome, this protein belongs to the following pathways:
MAP2K and MAPK activation  R-HSA-5674135  
MAPK1 (ERK2) activation  R-HSA-112411  
Negative feedback regulation of MAPK pathway  R-HSA-5674499  
RAF activation  R-HSA-5673000  
Signal transduction by L1  R-HSA-445144  
Signaling by FGFR1  R-HSA-5654736  
Signaling by FGFR2  R-HSA-5654738  
Signaling by FGFR3  R-HSA-5654741  
Signaling by FGFR4  R-HSA-5654743  
Uptake and function of anthrax toxins  R-HSA-5210891  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP2K2
GenomeRNAi: 5605
PRO: PR:P36507
Chemistry
GuidetoPHARMACOLOGY: 2063