CHRNA7 - Neuronal acetylcholine receptor subunit alpha-7 - human protein (Function)
 
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Protein
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CHRNA7 »  Neuronal acetylcholine receptor subunit alpha-7
 
Gene name:  CHRNA7
Entry whose protein(s) existence is based on evidence at protein level
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1 162 3
GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.7  
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166]  
1
  • UniProtKB
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • UniProtKB
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
3
  • MGI
  • UniProtKB
Acetylcholine-gated cation channel activitydefinition[GO:0022848]  
1
  • ParkinsonsUK-UCL
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • UniProtKB
Chloride channel regulator activitydefinition[GO:0017081]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Toxic substance bindingdefinition[GO:0015643]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • UniProtKB
Calcium ion transportdefinition[GO:0006816]  
2
  • UniProtKB
Cation transmembrane transportdefinition[GO:0098655]  
4
  • GOC
  • InterPro 2 GO
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • UniProtKB
Cognitiondefinition[GO:0050890]  
2
  • UniProtKB
Ion transmembrane transportdefinition[GO:0034220]  
1
  • ParkinsonsUK-UCL
Ion transportdefinition[GO:0006811]  
1
  • UniProtKB
Memorydefinition[GO:0007613]  
1
  • UniProtKB
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
2
  • MGI
  • UniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
2
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • UniProtKB
Response to hypoxiadefinition[GO:0001666]  
1
  • UniProtKB
Response to nicotinedefinition[GO:0035094]  
2
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+1139  
Cholinergic synapse  hsa04725+1139  
Neuroactive ligand-receptor interaction  hsa04080+1139  
According to Reactome, this protein belongs to the following pathway:
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors  REACT_22303  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNA7
GeneWiki: CHRFAM7A
PRO: PR:P36544
Chemistry
GuidetoPHARMACOLOGY: 468