CHRNA7 - Neuronal acetylcholine receptor subunit alpha-7 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CHRNA7 »  Neuronal acetylcholine receptor subunit alpha-7
 
Gene name:  CHRNA7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 157 3
GENE REF ISO

Function

 show evidences
Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.1.7  
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166]  
1
  • IDAUniProtKB
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • IDAUniProtKB
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
3
  • IDAMGI
  • IDAUniProtKB
Acetylcholine-gated cation channel activitydefinition[GO:0022848]  
1
  • IDAParkinsonsUK-UCL
Adenylate cyclase bindingdefinition[GO:0008179] silver  
  • IEAOrtholog Compara
ATPase bindingdefinition[GO:0051117] silver  
  • IEAOrtholog Compara
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • IPIUniProtKB
Chloride channel regulator activitydefinition[GO:0017081]  
1
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901] silver  
  • IEAOrtholog Compara
Scaffold protein bindingdefinition[GO:0097110] silver  
  • IEAOrtholog Compara
Toxic substance bindingdefinition[GO:0015643]  
1
  • IDAUniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDAUniProtKB
Associative learningdefinition[GO:0008306] silver  
  • IEAOrtholog Compara
B cell activationdefinition[GO:0042113] silver  
  • IEAOrtholog Compara
Behavioral response to ethanoldefinition[GO:0048149] silver  
  • IEAOrtholog Compara
Behavioral response to nicotinedefinition[GO:0035095] silver  
  • IEAOrtholog Compara
Calcium ion transportdefinition[GO:0006816]  
2
  • IMPUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IMPUniProtKB
Cognitiondefinition[GO:0050890]  
2
  • IMPUniProtKB
Dopamine biosynthetic processdefinition[GO:0042416] silver  
  • IEAOrtholog Compara
Endocytosisdefinition[GO:0006897] silver  
  • IEAOrtholog Compara
Generation of ovulation cycle rhythmdefinition[GO:0060112] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220]  
1
  • IDAParkinsonsUK-UCL
Ion transportdefinition[GO:0006811]  
1
  • NASUniProtKB
Memorydefinition[GO:0007613]  
1
  • NASUniProtKB
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-1 beta productiondefinition[GO:0032691] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-6 productiondefinition[GO:0032715] silver  
  • IEAOrtholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
2
  • IDAMGI
  • IMPUniProtKB
Neuronal action potentialdefinition[GO:0019228] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
2
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • IMPUniProtKB
Positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressuredefinition[GO:0001988] silver  
  • IEAOrtholog Compara
Regulation of norepinephrine secretiondefinition[GO:0014061] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmission, dopaminergicdefinition[GO:0032225] silver  
  • IEAOrtholog Compara
Response to fooddefinition[GO:0032094] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
Response to nicotinedefinition[GO:0035094]  
2
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Sperm motilitydefinition[GO:0030317] silver  
  • IEAOrtholog Compara
Synaptic transmission, cholinergicdefinition[GO:0007271] silver  
  • IEAOrtholog Compara
T cell activationdefinition[GO:0042110] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+1139  
Cholinergic synapse  hsa04725+1139  
Neuroactive ligand-receptor interaction  hsa04080+1139  
According to Reactome, this protein belongs to the following pathway:
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors  REACT_22303  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNA7
GeneWiki: CHRFAM7A
PRO: PR:P36544
Chemistry
GuidetoPHARMACOLOGY: 468