CPOX - Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial - human protein (Function)
 
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CPOX »  Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial   [ EC 1.3.3.3 ]  (COX)
 
Gene name:  CPOX
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.  
  • CuratedUniProtKB
GO molecular function 
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
Structural constituent of eye lensdefinition[GO:0005212] silver  
  • IEAOrtholog Compara
GO biological process 
Protoporphyrinogen IX biosynthetic processdefinition[GO:0006782]  
  • IEAUniPathway
Response to arsenic-containing substancedefinition[GO:0046685] silver  
  • IEAOrtholog Compara
Response to insecticidedefinition[GO:0017085] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Response to lead iondefinition[GO:0010288] silver  
  • IEAOrtholog Compara
Response to methylmercurydefinition[GO:0051597] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.3.3: Coproporphyrinogen-III + O(2) + 2 H(+) protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1371  
Porphyrin and chlorophyll metabolism  hsa00860+1371  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Heme biosynthesis  definition   [KW-0350]
Porphyrin biosynthesis  definition   [KW-0627]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links