BMPR1A - Bone morphogenetic protein receptor type-1A - human protein (Function)
 
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BMPR1A »  Bone morphogenetic protein receptor type-1A   [ EC 2.7.11.30 ]  (BMPR-1A)
 
Protein also known as:  Serine/threonine-protein kinase receptor R5 (SKR5); CD antigen CD292.
Gene name:  BMPR1A
Entry whose protein(s) existence is based on evidence at protein level
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1 78 1
GENE REF ISO

Function

 show evidences
Overview 
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAHGNC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAHGNC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
  • IEAOrtholog Compara
SMAD bindingdefinition[GO:0046332]  
1
  • IDAHGNC
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
  • IEAInterPro 2 GO
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
2
  • IDABHF-UCL
Cartilage developmentdefinition[GO:0051216] silver  
  • IEAOrtholog Compara
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
Dorsal/ventral axis specificationdefinition[GO:0009950] silver  
  • IEAOrtholog Compara
Ectoderm developmentdefinition[GO:0007398] silver  
  • IEAOrtholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Embryonic organ developmentdefinition[GO:0048568] silver  
  • IEAOrtholog Compara
Endocardial cushion formationdefinition[GO:0003272]  
  • ISSOrtholog Curator
Heart formationdefinition[GO:0060914] silver  
  • IEAOrtholog Compara
Hindlimb morphogenesisdefinition[GO:0035137] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • IMPBHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Lateral mesoderm developmentdefinition[GO:0048368] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Mesendoderm developmentdefinition[GO:0048382] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Mullerian duct regressiondefinition[GO:0001880] silver  
  • IEAOrtholog Compara
Negative regulation of neurogenesisdefinition[GO:0050768] silver  
  • IEAOrtholog Compara
Neural crest cell developmentdefinition[GO:0014032] silver  
  • IEAOrtholog Compara
Neural plate mediolateral regionalizationdefinition[GO:0021998] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Paraxial mesoderm structural organizationdefinition[GO:0048352] silver  
  • IEAOrtholog Compara
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IMPBHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IDABHF-UCL
Positive regulation of SMAD protein import into nucleusdefinition[GO:0060391]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAHGNC
Regulation of lateral mesodermal cell fate specificationdefinition[GO:0048378] silver  
  • IEAOrtholog Compara
Signal transduction by phosphorylationdefinition[GO:0023014]  
  • IEAInterPro 2 GO
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Stem cell maintenancedefinition[GO:0019827] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+657  
TGF-beta signaling pathway  hsa04350+657  
According to Reactome, this protein belongs to the following pathway:
Signaling by BMP  REACT_12034  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BMPR1A
GenomeRNAi: 657
PRO: PR:P36894
Chemistry
GuidetoPHARMACOLOGY: 1786