ACVR1B - Activin receptor type-1B - human protein (Function)
 
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ACVR1B »  Activin receptor type-1B   [ EC 2.7.11.30 ]
 
Protein also known as:  Serine/threonine-protein kinase receptor R2 (SKR2).
Gene name:  ACVR1B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.  
7
  • CuratedUniProtKB
GO molecular function 
Contributes to activin bindingdefinition[GO:0048185]  
1
  • IDAHGNC
Activin receptor activity, type Idefinition[GO:0016361]  
2
  • IDAUniProtKB
  • TASHGNC
Contributes to activin-activated receptor activitydefinition[GO:0017002]  
1
  • IDAHGNC
ATP bindingdefinition[GO:0005524]  
1
  • IDAHGNC
Contributes to growth factor bindingdefinition[GO:0019838]  
1
  • IPIHGNC
Inhibin bindingdefinition[GO:0034711]  
1
  • IPIBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIHGNC
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
  • IDAHGNC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAOrtholog Compara
SMAD bindingdefinition[GO:0046332]  
1
  • IDAHGNC
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
  • IEAInterPro 2 GO
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
1
  • NASHGNC
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • NASBHF-UCL
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
2
  • IDAUniProtKB
  • IMPBHF-UCL
Central nervous system developmentdefinition[GO:0007417] silver  
  • IEAOrtholog Compara
Development of primary female sexual characteristicsdefinition[GO:0046545] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • IMPBHF-UCL
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • IDAHGNC
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDAHGNC
Nodal signaling pathwaydefinition[GO:0038092]  
1
  • IGIUniProtKB
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • IDAUniProtKB
Positive regulation of activin receptor signaling pathwaydefinition[GO:0032927]  
1
  • IDABHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • IDAHGNC
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of trophoblast cell migrationdefinition[GO:1901165]  
1
  • IDABHF-UCL
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAHGNC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • IDAHGNC
Signal transductiondefinition[GO:0007165]  
2
  • IDAHGNC
Signal transduction by phosphorylationdefinition[GO:0023014] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein serine/threonine kinase signaling pathwaydefinition[GO:0007178]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cytokine-cytokine receptor interaction  hsa04060+91  
According to Reactome, this protein belongs to the following pathways:
Regulation of signaling by NODAL  REACT_111059  
Signaling by Activin  REACT_150238  
Signaling by NODAL  REACT_111057  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACVR1B
GenomeRNAi: 91
PRO: PR:P36896
Chemistry
GuidetoPHARMACOLOGY: 1787