ACVR1B - Activin receptor type-1B - human protein (Function)
 
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ACVR1B »  Activin receptor type-1B   [ EC 2.7.11.30 ]
 
Protein also known as:  Serine/threonine-protein kinase receptor R2 (SKR2).
Gene name:  ACVR1B
Entry whose protein(s) existence is based on evidence at protein level
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1 57 5
GENE REF ISO

Function

 show evidences
Overview 
Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.  
8
  • UniProtKB
GO molecular function 
Contributes to activin bindingdefinition[GO:0048185]  
1
  • HGNC
Activin receptor activity, type Idefinition[GO:0016361]  
2
  • UniProtKB
  • HGNC
Contributes to activin-activated receptor activitydefinition[GO:0017002]  
1
  • HGNC
ATP bindingdefinition[GO:0005524]  
1
  • HGNC
Contributes to growth factor bindingdefinition[GO:0019838]  
1
  • HGNC
Inhibin bindingdefinition[GO:0034711]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
  • HGNC
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • UniProtKB
  • HGNC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
1
  • Ortholog Compara
SMAD bindingdefinition[GO:0046332]  
1
  • HGNC
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
1
  • InterPro 2 GO
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
1
  • HGNC
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • BHF-UCL
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
2
  • UniProtKB
  • BHF-UCL
Central nervous system developmentdefinition[GO:0007417] silver  
1
  • Ortholog Compara
Development of primary female sexual characteristicsdefinition[GO:0046545] silver  
1
  • Ortholog Compara
Extrinsic apoptotic signaling pathwaydefinition[GO:0097191]  
1
  • BHF-UCL
G1/S transition of mitotic cell cycledefinition[GO:0000082]  
1
  • HGNC
Hair follicle developmentdefinition[GO:0001942] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • HGNC
Nodal signaling pathwaydefinition[GO:0038092]  
1
  • UniProtKB
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • UniProtKB
Positive regulation of activin receptor signaling pathwaydefinition[GO:0032927]  
1
  • BHF-UCL
Positive regulation of erythrocyte differentiationdefinition[GO:0045648]  
1
  • HGNC
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Positive regulation of trophoblast cell migrationdefinition[GO:1901165]  
1
  • BHF-UCL
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • HGNC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
2
  • HGNC
Signal transductiondefinition[GO:0007165]  
2
  • HGNC
Signal transduction by phosphorylationdefinition[GO:0023014]  
2
  • InterPro 2 GO
  • Ortholog Compara
Transmembrane receptor protein serine/threonine kinase signaling pathwaydefinition[GO:0007178]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activin receptor type-2 (ACVR2A or ACVR2B) activates the type-1 receptor through phosphorylation of its regulatory GS domain.  
3
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cytokine-cytokine receptor interaction  hsa04060+91  
According to Reactome, this protein belongs to the following pathways:
Regulation of signaling by NODAL  REACT_111059  
Signaling by Activin  REACT_150238  
Signaling by NODAL  REACT_111057  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACVR1B
GenomeRNAi: 91
PRO: PR:P36896
Chemistry
GuidetoPHARMACOLOGY: 1787