LTBR - Tumor necrosis factor receptor superfamily member 3 - human protein (Function)
 
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LTBR »  Tumor necrosis factor receptor superfamily member 3
 
Protein also known as:  Tumor necrosis factor receptor 2-related protein.
Gene name:  LTBR
Entry whose protein(s) existence is based on evidence at protein level
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1 58 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.  
2
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • IEPUniProtKB
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238]  
1
  • IMPUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • IEPUniProtKB
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • IMPUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+4055  
HTLV-I infection  hsa05166+4055  
Intestinal immune network for IgA production  hsa04672+4055  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Host-virus interaction  definition   [KW-0945]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Lymphotoxin_beta_receptor
GenomeRNAi: 4055
PRO: PR:P36941
Chemistry
GuidetoPHARMACOLOGY: 1872