SERPINF1 - Pigment epithelium-derived factor - human protein (Function)
 
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SERPINF1 »  Pigment epithelium-derived factor  (PEDF)
 
Protein also known as:  Cell proliferation-inducing gene 35 protein.
Gene name:  SERPINF1
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.  
3
  • UniProtKB
GO molecular function 
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867]  
1
  • RefGenome
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • PINC
Cellular response to cobalt iondefinition[GO:0071279] silver  
1
  • Ortholog Compara
Cellular response to dexamethasone stimulusdefinition[GO:0071549] silver  
1
  • Ortholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • UniProtKB
Negative regulation of endopeptidase activitydefinition[GO:0010951]  
1
  • RefGenome
Negative regulation of endothelial cell migrationdefinition[GO:0010596] silver  
1
  • Ortholog Compara
Negative regulation of epithelial cell proliferation involved in prostate gland developmentdefinition[GO:0060770] silver  
1
  • Ortholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
1
  • Ortholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
1
  • Ortholog Compara
Ovulation cycledefinition[GO:0042698] silver  
1
  • Ortholog Compara
Positive regulation of neurogenesisdefinition[GO:0050769]  
1
  • UniProtKB
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Regulation of proteolysisdefinition[GO:0030162]  
1
  • RefGenome
Response to acidic pHdefinition[GO:0010447] silver  
1
  • Ortholog Compara
Response to arsenic-containing substancedefinition[GO:0046685] silver  
1
  • Ortholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
1
  • Ortholog Compara
Short-term memorydefinition[GO:0007614] silver  
1
  • Ortholog Compara
Enzymatic activity 
 
More information is available from:
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PEDF
GenomeRNAi: 5176
PRO: PR:P36955