SERPINF1 - Pigment epithelium-derived factor - human protein (Function)
 
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SERPINF1 »  Pigment epithelium-derived factor
 
Gene name:  SERPINF1
Family name: Serpin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.  
2
  • CuratedUniProtKB
GO molecular function 
Serine-type endopeptidase inhibitor activitydefinition[GO:0004867] silver  
  • IBARefGenome
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IDAUniProtKB
Negative regulation of endopeptidase activitydefinition[GO:0010951] silver  
  • IBARefGenome
Negative regulation of epithelial cell proliferation involved in prostate gland developmentdefinition[GO:0060770] silver  
  • IEAOrtholog Compara
Negative regulation of inflammatory responsedefinition[GO:0050728] silver  
  • IEAOrtholog Compara
Positive regulation of neurogenesisdefinition[GO:0050769]  
1
  • IDAUniProtKB
Regulation of proteolysisdefinition[GO:0030162] silver  
  • IBARefGenome
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Short-term memorydefinition[GO:0007614] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PEDF
GenomeRNAi: 5176
PRO: PR:P36955