SREBF1 - Sterol regulatory element-binding protein 1 - human protein (Function)
 
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SREBF1 »  Sterol regulatory element-binding protein 1  (SREBP-1)
 
Protein also known as:  Sterol regulatory element-binding transcription factor 1. Cleaved into:  Processed sterol regulatory element-binding protein 1.
Gene name:  SREBF1
Family name: SREBP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 202 6
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • Ortholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein dimerization activitydefinition[GO:0046983] silver  
1
  • InterPro 2 GO
Protein kinase bindingdefinition[GO:0019901] silver  
1
  • Ortholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • HGNC
Sterol response element bindingdefinition[GO:0032810]  
1
  • HGNC
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cellular response to fatty aciddefinition[GO:0071398] silver  
1
  • Ortholog Compara
Cellular response to starvationdefinition[GO:0009267]  
1
  • HGNC
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Insulin receptor signaling pathwaydefinition[GO:0008286] silver  
1
  • Ortholog Compara
Lipid biosynthetic processdefinition[GO:0008610]  
1
  • Ortholog Curator
Lipid metabolic processdefinition[GO:0006629]  
1
  • PINC
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Negative regulation of insulin secretiondefinition[GO:0046676] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Positive regulation of cholesterol biosynthetic processdefinition[GO:0045542] silver  
1
  • Ortholog Compara
Positive regulation of histone deacetylationdefinition[GO:0031065] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
  • Ortholog Compara
Positive regulation of triglyceride biosynthetic processdefinition[GO:0010867]  
1
  • Ortholog Curator
Regulation of fatty acid metabolic processdefinition[GO:0019217] silver  
1
  • Ortholog Compara
Regulation of heart rate by chemical signaldefinition[GO:0003062] silver  
1
  • Ortholog Compara
Regulation of mitochondrion degradationdefinition[GO:1903146]  
1
  • ParkinsonsUK-UCL
Regulation of protein targeting to mitochondriondefinition[GO:1903214]  
1
  • ParkinsonsUK-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to fooddefinition[GO:0032094] silver  
1
  • Ortholog Compara
Response to glucagondefinition[GO:0033762] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Response to progesteronedefinition[GO:0032570] silver  
1
  • Ortholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Insulin signaling pathway  hsa04910+6720  
According to Reactome, this protein belongs to the following pathways:
Activation of gene expression by SREBF (SREBP)  REACT_147904  
PPARA activates gene expression  REACT_116145  
Regulation of cholesterol biosynthesis by SREBP (SREBF)  REACT_147797  
RORA activates circadian gene expression  REACT_118659  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SREBF1
GenomeRNAi: 6720
PRO: PR:P36956