ACVRL1 - Serine/threonine-protein kinase receptor R3 - human protein (Function)
 
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ACVRL1 »  Serine/threonine-protein kinase receptor R3   [ EC 2.7.11.30 ]  (SKR3)
 
Protein also known as:  TGF-B superfamily receptor type I (TSR-I).
Gene name:  ACVRL1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.  
2
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185]  
1
  • IDAUniProtKB
Contributes to activin receptor activity, type Idefinition[GO:0016361]  
2
  • TASUniProtKB
  • IDAMGI
ATP bindingdefinition[GO:0005524]  
1
  • IDAHGNC
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
10
  • IPIBHF-UCL
  • IPIHGNC
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAHGNC
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAOrtholog Compara
SMAD bindingdefinition[GO:0046332]  
1
  • IDAHGNC
Transforming growth factor beta bindingdefinition[GO:0050431]  
1
  • IPIUniProtKB
Contributes to transforming growth factor beta receptor activity, type Idefinition[GO:0005025]  
1
  • IDAUniProtKB
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024]  
1
  • IDAMGI
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
1
  • RCAUniProtKB
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IDAGOC
Angiogenesisdefinition[GO:0001525]  
1
  • IMPHGNC
Artery developmentdefinition[GO:0060840]  
  • ISSOrtholog Curator
Blood circulationdefinition[GO:0008015]  
1
  • IMPHGNC
Blood vessel endothelial cell proliferation involved in sprouting angiogenesisdefinition[GO:0002043]  
1
  • TASDFLAT
Blood vessel maturationdefinition[GO:0001955]  
1
  • TASDFLAT
Blood vessel remodelingdefinition[GO:0001974]  
  • ISSOrtholog Curator
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IMPBHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773]  
1
  • IMPBHF-UCL
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • IDABHF-UCL
Endothelial tube morphogenesisdefinition[GO:0061154]  
1
  • IMPBHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Lymphangiogenesisdefinition[GO:0001946]  
  • ISSOrtholog Curator
Lymphatic endothelial cell differentiationdefinition[GO:0060836]  
1
  • IMPBHF-UCL
Negative regulation of blood vessel endothelial cell migrationdefinition[GO:0043537]  
1
  • IMPBHF-UCL
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • IMPHGNC
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDABHF-UCL
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IMPHGNC
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPHGNC
Negative regulation of DNA biosynthetic processdefinition[GO:2000279]  
1
  • IMPBHF-UCL
Negative regulation of endothelial cell differentiationdefinition[GO:0045602] silver  
  • IEAOrtholog Compara
Negative regulation of endothelial cell migrationdefinition[GO:0010596]  
1
  • IDABHF-UCL
Negative regulation of endothelial cell proliferationdefinition[GO:0001937] silver  
  • IEAOrtholog Compara
Negative regulation of focal adhesion assemblydefinition[GO:0051895]  
1
  • IMPHGNC
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
1
  • IDABHF-UCL
Positive regulation of chondrocyte differentiationdefinition[GO:0032332]  
1
  • TASBHF-UCL
Positive regulation of endothelial cell differentiationdefinition[GO:0045603] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAHGNC
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAHGNC
Regulation of blood pressuredefinition[GO:0008217]  
1
  • IMPHGNC
Regulation of blood vessel endothelial cell migrationdefinition[GO:0043535]  
1
  • TASDFLAT
Regulation of DNA replicationdefinition[GO:0006275]  
1
  • TASDFLAT
Regulation of endothelial cell proliferationdefinition[GO:0001936]  
1
  • TASDFLAT
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IMPHGNC
Retina vasculature development in camera-type eyedefinition[GO:0061298]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IDAHGNC
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
1
  • IDAHGNC
Venous blood vessel developmentdefinition[GO:0060841]  
  • ISSOrtholog Curator
Wound healing, spreading of epidermal cellsdefinition[GO:0035313]  
1
  • IMPHGNC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACVRL1
GenomeRNAi: 94
PRO: PR:P37023
Chemistry
GuidetoPHARMACOLOGY: 1784