SCNN1A - Amiloride-sensitive sodium channel subunit alpha - human protein (Function)
 
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SCNN1A »  Amiloride-sensitive sodium channel subunit alpha
 
Protein also known as:  Nonvoltage-gated sodium channel 1 subunit alpha.
Gene name:  SCNN1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the epithelial na(+) channel (enac) family  1.A.6.1.1  
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Contributes to ligand-gated sodium channel activitydefinition[GO:0015280]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
WW domain bindingdefinition[GO:0050699]  
1
  • IPIBHF-UCL
GO biological process 
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Multicellular organismal water homeostasisdefinition[GO:0050891]  
1
  • IDAUniProtKB
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Sensory perception of tastedefinition[GO:0050909]  
  • IEAUniProtKB KW
Sodium ion homeostasisdefinition[GO:0055078]  
1
  • IDAUniProtKB
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • IDAUniProtKB
Sodium ion transportdefinition[GO:0006814]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Activated by WNK1, WNK2, WNK3 and WNK4 (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+6337  
Taste transduction  hsa04742+6337  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Sodium transport  definition   [KW-0739]
Taste  definition   [KW-0919]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SCNN1A
GenomeRNAi: 6337
PRO: PR:P37088