TGFBR2 - TGF-beta receptor type-2 - human protein (Function)
 
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TGFBR2 »  TGF-beta receptor type-2   [ EC 2.7.11.30 ]  (TGFR-2)
 
Protein also known as:  Transforming growth factor-beta receptor type II (TbetaR-II).
Gene name:  TGFBR2
Entry whose protein(s) existence is based on evidence at protein level
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1 287 2
GENE REF ISO

Function

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Overview 
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Glycosaminoglycan bindingdefinition[GO:0005539]  
1
  • IDABHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Mitogen-activated protein kinase kinase kinase bindingdefinition[GO:0031435] silver  
  • IEAOrtholog Compara
Contributes to protein bindingdefinition[GO:0005515]  
20
  • IPIAgBase
  • IPIIntAct
  • IPIBHF-UCL
  • IPIHGNC
  • IPIUniProtKB
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAInterPro 2 GO
SMAD bindingdefinition[GO:0046332]  
2
  • IDABHF-UCL
Transforming growth factor beta bindingdefinition[GO:0050431]  
6
  • IDABHF-UCL
Transforming growth factor beta receptor activity, type IIdefinition[GO:0005026] silver  
  • IEAInterPro 2 GO
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024]  
4
  • IDABHF-UCL
Transmembrane receptor protein serine/threonine kinase activitydefinition[GO:0004675]  
1
  • IDABHF-UCL
Type I transforming growth factor beta receptor bindingdefinition[GO:0034713]  
2
  • IDABHF-UCL
Isoform  Iso 2   Type III transforming growth factor beta receptor bindingdefinition[GO:0034714]  
1
  • IDABHF-UCL
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
  • ISSOrtholog Curator
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • IDAUniProtKB
Blood vessel developmentdefinition[GO:0001568]  
1
  • TASBHF-UCL
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Bronchus morphogenesisdefinition[GO:0060434] silver  
  • IEAOrtholog Compara
Cartilage developmentdefinition[GO:0051216] silver  
  • IEAOrtholog Compara
Common-partner SMAD protein phosphorylationdefinition[GO:0007182] silver  
  • IEAOrtholog Compara
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
  • ISSOrtholog Curator
Embryonic hemopoiesisdefinition[GO:0035162]  
  • ISSOrtholog Curator
Gastrulationdefinition[GO:0007369] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Lens development in camera-type eyedefinition[GO:0002088] silver  
  • IEAOrtholog Compara
Lens fiber cell apoptotic processdefinition[GO:1990086] silver  
  • IEAOrtholog Compara
Lung lobe morphogenesisdefinition[GO:0060463] silver  
  • IEAOrtholog Compara
Mammary gland morphogenesisdefinition[GO:0060443] silver  
  • IEAOrtholog Compara
Myeloid dendritic cell differentiationdefinition[GO:0043011]  
  • ISSOrtholog Curator
Negative regulation of cardiac muscle cell proliferationdefinition[GO:0060044] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Pathway-restricted SMAD protein phosphorylationdefinition[GO:0060389]  
2
  • IDABHF-UCL
Patterning of blood vesselsdefinition[GO:0001569]  
  • ISSOrtholog Curator
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • IDABHF-UCL
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • IDABHF-UCL
Positive regulation of B cell tolerance inductiondefinition[GO:0002663]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of epithelial cell migrationdefinition[GO:0010634] silver  
  • IEAOrtholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053]  
  • ISSOrtholog Curator
Positive regulation of NK T cell differentiationdefinition[GO:0051138]  
  • ISSOrtholog Curator
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379]  
1
  • IMPBHF-UCL
Positive regulation of skeletal muscle tissue regenerationdefinition[GO:0043415] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of T cell tolerance inductiondefinition[GO:0002666]  
  • ISSOrtholog Curator
Positive regulation of tolerance induction to self antigendefinition[GO:0002651]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDABHF-UCL
Receptor-mediated endocytosisdefinition[GO:0006898] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127]  
  • ISSOrtholog Curator
Response to cholesteroldefinition[GO:0070723]  
1
  • IDABHF-UCL
Response to drugdefinition[GO:0042493]  
1
  • IDABHF-UCL
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Response to mechanical stimulusdefinition[GO:0009612] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Signal transduction by phosphorylationdefinition[GO:0023014]  
  • IEAInterPro 2 GO
Smoothened signaling pathwaydefinition[GO:0007224] silver  
  • IEAOrtholog Compara
Trachea formationdefinition[GO:0060440] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
4
  • IDABHF-UCL
Vasculogenesisdefinition[GO:0001570]  
  • ISSOrtholog Curator
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+7048  
Chagas disease (American trypanosomiasis)  hsa05142+7048  
Chronic myeloid leukemia  hsa05220+7048  
Colorectal cancer  hsa05210+7048  
Cytokine-cytokine receptor interaction  hsa04060+7048  
Endocytosis  hsa04144+7048  
HTLV-I infection  hsa05166+7048  
MAPK signaling pathway  hsa04010+7048  
Osteoclast differentiation  hsa04380+7048  
Pancreatic cancer  hsa05212+7048  
Pathways in cancer  hsa05200+7048  
TGF-beta signaling pathway  hsa04350+7048  
According to Reactome, this protein belongs to the following pathways:
Downregulation of TGF-beta receptor signaling  REACT_120727  
SMAD2/3 MH2 Domain Mutants in Cancer  REACT_169165  
SMAD2/3 Phosphorylation Motif Mutants in Cancer  REACT_169103  
TGF-beta receptor signaling activates SMADs  REACT_120850  
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)  REACT_120726  
TGFBR1 KD Mutants in Cancer  REACT_169263  
TGFBR1 LBD Mutants in Cancer  REACT_169445  
TGFBR2 Kinase Domain Mutants in Cancer  REACT_169440  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Differentiation  definition   [KW-0221]
Growth regulation  definition   [KW-0341]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TGF_beta_receptor_2
GenomeRNAi: 7048
PRO: PR:P37173
Chemistry
GuidetoPHARMACOLOGY: 1795