AVPR1A - Vasopressin V1a receptor - human protein (Function)
 
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AVPR1A »  Vasopressin V1a receptor  (V1aR)
 
Protein also known as:  Vascular/hepatic-type arginine vasopressin receptor.
Gene name:  AVPR1A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.  
1
  • CuratedUniProtKB
GO molecular function 
Peptide hormone bindingdefinition[GO:0017046] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • TASPINC
V1A vasopressin receptor bindingdefinition[GO:0031894] silver  
  • IEAOrtholog Compara
Vasopressin receptor activitydefinition[GO:0005000] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • TASPINC
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Calcium-mediated signalingdefinition[GO:0019722] silver  
  • IEAOrtholog Compara
Cellular response to water deprivationdefinition[GO:0042631] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Grooming behaviordefinition[GO:0007625] silver  
  • IEAOrtholog Compara
Maternal aggressive behaviordefinition[GO:0002125] silver  
  • IEAOrtholog Compara
Maternal behaviordefinition[GO:0042711] silver  
  • IEAOrtholog Compara
Myotube differentiationdefinition[GO:0014902] silver  
  • IEAOrtholog Compara
Negative regulation of female receptivitydefinition[GO:0007621] silver  
  • IEAOrtholog Compara
Negative regulation of transmission of nerve impulsedefinition[GO:0051970] silver  
  • IEAOrtholog Compara
Penile erectiondefinition[GO:0043084] silver  
  • IEAOrtholog Compara
Positive regulation of cell growthdefinition[GO:0030307] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cellular pH reductiondefinition[GO:0032849] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of glutamate secretiondefinition[GO:0014049] silver  
  • IEAOrtholog Compara
Positive regulation of heart ratedefinition[GO:0010460] silver  
  • IEAOrtholog Compara
Positive regulation of prostaglandin biosynthetic processdefinition[GO:0031394] silver  
  • IEAOrtholog Compara
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of systemic arterial blood pressuredefinition[GO:0003084] silver  
  • IEAOrtholog Compara
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressure by vasopressindefinition[GO:0001992] silver  
  • IEAOrtholog Compara
Response to corticosteronedefinition[GO:0051412] silver  
  • IEAOrtholog Compara
Social behaviordefinition[GO:0035176] silver  
  • IEAOrtholog Compara
Sperm ejaculationdefinition[GO:0042713] silver  
  • IEAOrtholog Compara
Telencephalon developmentdefinition[GO:0021537] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+552  
Neuroactive ligand-receptor interaction  hsa04080+552  
Vascular smooth muscle contraction  hsa04270+552  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
Note 
Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Arginine_vasopressin_receptor_1A
GenomeRNAi: 552
PRO: PR:P37288
Chemistry
GuidetoPHARMACOLOGY: 366