SNCA - Alpha-synuclein - human protein (Function)
 
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SNCA »  Alpha-synuclein
 
Protein also known as:  Non-A4 component of amyloid precursor (NACP).
Gene name:  SNCA
Family name: Synuclein
Entry whose protein(s) existence is based on evidence at protein level
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1 941 3
GENE REF ISO

Function

 show evidences
Overview 
May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the synuclein (synuclein) family  1.C.77.1.1  
GO molecular function 
Alpha-tubulin bindingdefinition[GO:0043014]  
1
  • UniProtKB
Beta-tubulin bindingdefinition[GO:0048487] silver  
1
  • Ortholog Compara
Calcium ion bindingdefinition[GO:0005509]  
2
  • UniProtKB
Copper ion bindingdefinition[GO:0005507]  
2
  • UniProtKB
Cysteine-type endopeptidase inhibitor activity involved in apoptotic processdefinition[GO:0043027]  
1
  • UniProtKB
Dynein bindingdefinition[GO:0045502]  
1
  • UniProtKB
Not  Fatty acid bindingdefinition[GO:0005504]  
1
  • UniProtKB
Ferrous iron bindingdefinition[GO:0008198]  
1
  • UniProtKB
Histone bindingdefinition[GO:0042393]  
1
  • UniProtKB
Hsp70 protein bindingdefinition[GO:0030544]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
9
  • IntAct
Kinesin bindingdefinition[GO:0019894]  
1
  • UniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Microtubule bindingdefinition[GO:0008017] silver  
1
  • Ortholog Compara
Oxidoreductase activitydefinition[GO:0016491]  
1
  • UniProtKB
Phospholipase bindingdefinition[GO:0043274] silver  
1
  • Ortholog Compara
Not  Phospholipase D inhibitor activitydefinition[GO:0060961]  
1
  • UniProtKB
Phospholipid bindingdefinition[GO:0005543]  
1
  • ParkinsonsUK-UCL
Phosphoprotein bindingdefinition[GO:0051219]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
19
  • IntAct
  • UniProtKB
  • HGNC
  • BHF-UCL
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Protein N-terminus bindingdefinition[GO:0047485] silver  
1
  • Ortholog Compara
Tau protein bindingdefinition[GO:0048156]  
2
  • BHF-UCL
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • ParkinsonsUK-UCL
Zinc ion bindingdefinition[GO:0008270]  
1
  • UniProtKB
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
1
  • BHF-UCL
Adult locomotory behaviordefinition[GO:0008344] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Behavioral response to cocainedefinition[GO:0048148] silver  
1
  • Ortholog Compara
Not  Calcium ion homeostasisdefinition[GO:0055074]  
1
  • UniProtKB
Cellular response to copper iondefinition[GO:0071280]  
1
  • UniProtKB
Cellular response to epinephrine stimulusdefinition[GO:0071872]  
1
  • UniProtKB
Cellular response to fibroblast growth factor stimulusdefinition[GO:0044344] silver  
1
  • Ortholog Compara
Cellular response to oxidative stressdefinition[GO:0034599]  
1
  • ParkinsonsUK-UCL
Dopamine biosynthetic processdefinition[GO:0042416]  
1
  • UniProtKB
Dopamine uptake involved in synaptic transmissiondefinition[GO:0051583]  
1
  • UniProtKB
Extracellular fibril organizationdefinition[GO:0043206]  
1
  • UniProtKB
Fatty acid metabolic processdefinition[GO:0006631] silver  
1
  • Ortholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Microglial cell activationdefinition[GO:0001774]  
1
  • ParkinsonsUK-UCL
Mitochondrial ATP synthesis coupled electron transportdefinition[GO:0042775] silver  
1
  • Ortholog Compara
Mitochondrial membrane organizationdefinition[GO:0007006] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043154]  
1
  • UniProtKB
Negative regulation of dopamine metabolic processdefinition[GO:0045963] silver  
1
  • Ortholog Compara
Negative regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051585]  
1
  • UniProtKB
Negative regulation of exocytosisdefinition[GO:0045920]  
1
  • UniProtKB
Negative regulation of histone acetylationdefinition[GO:0035067]  
1
  • UniProtKB
Negative regulation of microtubule polymerizationdefinition[GO:0031115]  
1
  • BHF-UCL
Negative regulation of mitochondrial electron transport, NADH to ubiquinonedefinition[GO:1902957]  
1
  • ParkinsonsUK-UCL
Negative regulation of monooxygenase activitydefinition[GO:0032769]  
1
  • BHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of norepinephrine uptakedefinition[GO:0051622]  
1
  • UniProtKB
Negative regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010642]  
1
  • UniProtKB
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
1
  • Ortholog Compara
Negative regulation of serotonin uptakedefinition[GO:0051612]  
1
  • UniProtKB
Negative regulation of thrombin receptor signaling pathwaydefinition[GO:0070495]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • ParkinsonsUK-UCL
Negative regulation of transporter activitydefinition[GO:0032410]  
1
  • UniProtKB
Neutral lipid metabolic processdefinition[GO:0006638] silver  
1
  • Ortholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB
Phospholipid metabolic processdefinition[GO:0006644] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • ParkinsonsUK-UCL
Positive regulation of endocytosisdefinition[GO:0045807]  
1
  • UniProtKB
Positive regulation of glutathione peroxidase activitydefinition[GO:1903284]  
1
  • ParkinsonsUK-UCL
Positive regulation of hydrogen peroxide catabolic processdefinition[GO:1903285]  
1
  • ParkinsonsUK-UCL
Positive regulation of inositol phosphate biosynthetic processdefinition[GO:0060732]  
1
  • UniProtKB
Positive regulation of neurotransmitter secretiondefinition[GO:0001956] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • Ortholog Curator
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902]  
1
  • BHF-UCL
Positive regulation of receptor recyclingdefinition[GO:0001921]  
1
  • UniProtKB
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
1
  • UniProtKB
Protein destabilizationdefinition[GO:0031648]  
1
  • UniProtKB
Receptor internalizationdefinition[GO:0031623]  
1
  • UniProtKB
Regulation of acyl-CoA biosynthetic processdefinition[GO:0050812] silver  
1
  • Ortholog Compara
Regulation of dopamine secretiondefinition[GO:0014059]  
1
  • UniProtKB
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
1
  • Ortholog Compara
Regulation of glutamate secretiondefinition[GO:0014048] silver  
1
  • Ortholog Compara
Regulation of locomotiondefinition[GO:0040012] silver  
1
  • Ortholog Compara
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169] silver  
1
  • Ortholog Compara
Regulation of macrophage activationdefinition[GO:0043030] silver  
1
  • Ortholog Compara
Regulation of phospholipase activitydefinition[GO:0010517]  
1
  • UniProtKB
Regulation of reactive oxygen species biosynthetic processdefinition[GO:1903426]  
1
  • ParkinsonsUK-UCL
Regulation of synaptic vesicle recyclingdefinition[GO:1903421]  
1
  • ParkinsonsUK-UCL
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to interferon-gammadefinition[GO:0034341]  
1
  • UniProtKB
Response to interleukin-1definition[GO:0070555]  
1
  • UniProtKB
Response to iron(II) iondefinition[GO:0010040]  
1
  • UniProtKB
Response to lipopolysaccharidedefinition[GO:0032496]  
1
  • UniProtKB
Response to magnesium iondefinition[GO:0032026]  
1
  • UniProtKB
Synapse organizationdefinition[GO:0050808] silver  
1
  • Ortholog Compara
Synaptic vesicle endocytosisdefinition[GO:0048488]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+6622  
Parkinson's disease  hsa05012+6622  
According to Reactome, this protein belongs to the following pathway:
Amyloids  REACT_75925  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Alpha-synuclein
GenomeRNAi: 6622
PRO: PR:P37840