BRCA1 - Breast cancer type 1 susceptibility protein - human protein (Function)
 
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BRCA1 »  Breast cancer type 1 susceptibility protein   [ EC 6.3.2.- ]
 
Protein also known as:  RING finger protein 53.
Gene name:  BRCA1
Entry whose protein(s) existence is based on evidence at protein level
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1 204 6
GENE REF ISO

Function

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Overview 
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.  
15
  • CuratedUniProtKB
GO molecular function 
Androgen receptor bindingdefinition[GO:0050681]  
1
  • NASUniProtKB
DNA bindingdefinition[GO:0003677]  
1
  • TASPINC
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
46
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
RNA bindingdefinition[GO:0003723]  
1
  • IDAMGI
Transcription coactivator activitydefinition[GO:0003713]  
1
  • NASUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
Tubulin bindingdefinition[GO:0015631]  
1
  • NASUniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIUniProtKB
Contributes to ubiquitin-protein ligase activitydefinition[GO:0004842]  
4
  • IDAUniProtKB
  • IDAHGNC
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • NASUniProtKB
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
1
  • TASPINC
Cellular response to indole-3-methanoldefinition[GO:0071681]  
1
  • IDAUniProtKB
Chromosome segregationdefinition[GO:0007059]  
1
  • IMPUniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatordefinition[GO:0006978]  
1
  • TASUniProtKB
Double-strand break repairdefinition[GO:0006302]  
3
  • IMPUniProtKB
Double-strand break repair via homologous recombinationdefinition[GO:0000724]  
1
  • IDAHGNC
Fatty acid biosynthetic processdefinition[GO:0006633]  
  • IEAUniProtKB KW
G2 DNA damage checkpointdefinition[GO:0031572]  
3
  • IMPUniProtKB
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
1
  • IDAMGI
Negative regulation of centriole replicationdefinition[GO:0046600]  
1
  • NASUniProtKB
Negative regulation of fatty acid biosynthetic processdefinition[GO:0045717]  
1
  • IMPUniProtKB
Negative regulation of histone H3-K9 methylationdefinition[GO:0051573]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Positive regulation of cell cycle arrestdefinition[GO:0071158]  
1
  • IDABHF-UCL
Positive regulation of DNA repairdefinition[GO:0045739]  
3
  • IMPUniProtKB
Positive regulation of histone acetylationdefinition[GO:0035066]  
1
  • IDABHF-UCL
Positive regulation of histone H3-K4 methylationdefinition[GO:0051571]  
1
  • IDABHF-UCL
Positive regulation of histone H3-K9 acetylationdefinition[GO:2000617]  
1
  • IDABHF-UCL
Positive regulation of histone H4-K16 acetylationdefinition[GO:2000620]  
1
  • IDABHF-UCL
Positive regulation of histone H4-K20 methylationdefinition[GO:0070512]  
1
  • IDABHF-UCL
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPBHF-UCL
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • NASUniProtKB
Postreplication repairdefinition[GO:0006301]  
1
  • IDAHGNC
Protein autoubiquitinationdefinition[GO:0051865]  
2
  • IDAUniProtKB
Protein K6-linked ubiquitinationdefinition[GO:0085020]  
2
  • IDAUniProtKB
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IDAHGNC
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • IDABHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • TASUniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • TASPINC
Regulation of transcription from RNA polymerase III promoterdefinition[GO:0006359]  
1
  • TASUniProtKB
Response to estrogendefinition[GO:0043627]  
1
  • IDAUniProtKB
Response to ionizing radiationdefinition[GO:0010212]  
3
  • IMPUniProtKB
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • IDABHF-UCL
Enzymatic activity 
It is regulated in the following manner
The E3 ubiquitin-protein ligase activity is inhibited by phosphorylation by AURKA. Activity is increased by phosphatase treatment.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Fanconi anemia pathway  hsa03460+672  
Ubiquitin mediated proteolysis  hsa04120+672  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
DNA Repair  REACT_216  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
DNA damage  definition   [KW-0227]
DNA recombination  definition   [KW-0233]
DNA repair  definition   [KW-0234]
Fatty acid biosynthesis  definition   [KW-0275]
Fatty acid metabolism  definition   [KW-0276]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BRCA1
GenomeRNAi: 672
PRO: PR:P38398