IFNGR2 - Interferon gamma receptor 2 - human protein (Function)
 
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Protein
Gene
References

 
IFNGR2 »  Interferon gamma receptor 2  (IFN-gamma-R2)
 
Protein also known as:  Interferon gamma receptor accessory factor 1 (AF-1).
Gene name:  IFNGR2
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

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Overview 
Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.  
  • CuratedUniProtKB
GO molecular function 
Interferon-gamma receptor activitydefinition[GO:0004906]  
1
  • TASPINC
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Response to virusdefinition[GO:0009615]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chagas disease (American trypanosomiasis)  hsa05142+3460  
Cytokine-cytokine receptor interaction  hsa04060+3460  
Herpes simplex infection  hsa05168+3460  
Influenza A  hsa05164+3460  
Jak-STAT signaling pathway  hsa04630+3460  
Leishmaniasis  hsa05140+3460  
Measles  hsa05162+3460  
Natural killer cell mediated cytotoxicity  hsa04650+3460  
Osteoclast differentiation  hsa04380+3460  
Salmonella infection  hsa05132+3460  
Toxoplasmosis  hsa05145+3460  
Tuberculosis  hsa05152+3460  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3460
PRO: PR:P38484