ATP6V1A - V-type proton ATPase catalytic subunit A - human protein (Function)
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ATP6V1A »  V-type proton ATPase catalytic subunit A   [ EC ]  (V-ATPase subunit A)
Protein also known as:  Vacuolar proton pump subunit alpha.
Gene name:  ATP6V1A
Entry whose protein(s) existence is based on evidence at protein level
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Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Proton-transporting ATPase activity, rotational mechanismdefinition[GO:0046961] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
ATP metabolic processdefinition[GO:0046034] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP + H(2)O + H(+)(In) ADP + phosphate + H(+)(Out).  
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+523  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+523  
Metabolic pathways  hsa01100+523  
Oxidative phosphorylation  hsa00190+523  
Phagosome  hsa04145+523  
Rheumatoid arthritis  hsa05323+523  
Synaptic vesicle cycle  hsa04721+523  
Vibrio cholerae infection  hsa05110+523  
According to Reactome, this protein belongs to the following pathways:
Insulin receptor recycling  REACT_1109  
Phagosomal maturation (early endosomal stage)  REACT_121256  
Transferrin endocytosis and recycling  REACT_25283  
More information is available from:


Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ATP6V1A
GenomeRNAi: 523
PRO: PR:P38606