ATP6V1A - V-type proton ATPase catalytic subunit A - human protein (Function)
 
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ATP6V1A »  V-type proton ATPase catalytic subunit A   [ EC 3.6.3.14 ]  (V-ATPase subunit A)
 
Protein also known as:  Vacuolar proton pump subunit alpha.
Gene name:  ATP6V1A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily  3.A.2.2.4  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Proton-transporting ATPase activity, rotational mechanismdefinition[GO:0046961] silver  
  • IEAInterPro 2 GO
GO biological process 
ATP hydrolysis coupled proton transportdefinition[GO:0015991] silver  
  • IEAInterPro 2 GO
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.14: ATP + H(2)O + H(+)(In) ADP + phosphate + H(+)(Out).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Collecting duct acid secretion  hsa04966+523  
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+523  
Metabolic pathways  hsa01100+523  
Oxidative phosphorylation  hsa00190+523  
Phagosome  hsa04145+523  
Rheumatoid arthritis  hsa05323+523  
Synaptic vesicle cycle  hsa04721+523  
Vibrio cholerae infection  hsa05110+523  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Hydrogen ion transport  definition   [KW-0375]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP6V1A
GenomeRNAi: 523
PRO: PR:P38606