COL18A1 - Collagen alpha-1(XVIII) chain - human protein (Function)
 
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Protein
Gene
References

 
COL18A1 »  Collagen alpha-1(XVIII) chain
 
Cleaved into:  Endostatin.
Gene name:  COL18A1
Family name: Multiplexin collagen
Entry whose protein(s) existence is based on evidence at protein level
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1 44 3
GENE REF ISO

Function

 show evidences
Overview 
COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.  
1
  • UniProtKB
Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.  
1
  • UniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Structural molecule activitydefinition[GO:0005198] silver  
1
  • InterPro 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • UniProtKB KW
Endothelial cell morphogenesisdefinition[GO:0001886] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Organ morphogenesisdefinition[GO:0009887]  
1
  • PINC
Positive regulation of cell migrationdefinition[GO:0030335] silver  
1
  • Ortholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353] silver  
1
  • Ortholog Compara
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to hydrostatic pressuredefinition[GO:0051599] silver  
1
  • Ortholog Compara
Visual perceptiondefinition[GO:0007601]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein digestion and absorption  hsa04974+80781  
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Assembly of collagen fibrils and other multimeric structures  REACT_150180  
Collagen biosynthesis and modifying enzymes  REACT_121139  
Collagen degradation  REACT_150401  
Integrin cell surface interactions  REACT_13552  
Laminin interactions  REACT_169262  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links