CUX1 - Homeobox protein cut-like 1 - human protein (Function)
 
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CUX1 »  Homeobox protein cut-like 1
 
Protein also known as:  CCAAT displacement protein (CDP).
Gene name:  CUX1
Family name: CUT homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity).  
1
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001205] silver  
1
  • Ortholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • Ortholog Curator
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • UniProtKB
GO biological process 
Auditory receptor cell differentiationdefinition[GO:0042491] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • PINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Positive regulation of dendrite morphogenesisdefinition[GO:0050775]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • PINC
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signaling by FGFR1 fusion mutants  REACT_121141  
Note 
Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.  
1
  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CUTL1
GenomeRNAi: 1523
PRO: PR:P39880