MMP12 - Macrophage metalloelastase - human protein (Function)
 
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MMP12 »  Macrophage metalloelastase   [ EC 3.4.24.65 ]  (MME)
 
Protein also known as:  Matrix metalloproteinase-12 (MMP-12).
Gene name:  MMP12
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.  
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  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
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  • InterPro 2 GO
Endopeptidase activitydefinition[GO:0004175]  
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  • UniProtKB
Metalloendopeptidase activitydefinition[GO:0004222]  
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  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
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  • InterPro 2 GO
GO biological process 
Positive regulation of epithelial cell proliferation involved in wound healingdefinition[GO:0060054]  
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  • BHF-UCL
Proteolysisdefinition[GO:0006508]  
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  • UniProtKB KW
Wound healing, spreading of epidermal cellsdefinition[GO:0035313]  
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  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.65: Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin.  
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  • UniProtKB
It requires the following cofactors
 Ca(2+) : Binds 4 Ca(2+) ions per subunit.  
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  • UniProtKB
 Zn(2+) : Binds 2 Zn(2+) ions per subunit.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Matrix_metallopeptidase_12
GenomeRNAi: 4321
PRO: PR:P39900
Chemistry
GuidetoPHARMACOLOGY: 1636