DCT - L-dopachrome tautomerase - human protein (Function)
 
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DCT »  L-dopachrome tautomerase   [ EC 5.3.3.12 ]  (DT)
 
Protein also known as:  L-dopachrome Delta-isomerase.
Gene name:  DCT
Family name: Tyrosinase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in regulating eumelanin and phaeomelanin levels.  
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  • UniProtKB
GO molecular function 
Copper ion bindingdefinition[GO:0005507]  
1
  • PINC
Dopachrome isomerase activitydefinition[GO:0004167]  
1
  • Ortholog Curator
GO biological process 
Cell developmentdefinition[GO:0048468] silver  
1
  • Ortholog Compara
Developmental pigmentationdefinition[GO:0048066] silver  
1
  • Ortholog Compara
Epidermis developmentdefinition[GO:0008544]  
1
  • PINC
Melanin biosynthetic process from tyrosinedefinition[GO:0006583]  
1
  • Ortholog Curator
Oxidation-reduction processdefinition[GO:0055114]  
1
  • InterPro 2 GO
Positive regulation of neuroblast proliferationdefinition[GO:0002052] silver  
1
  • Ortholog Compara
Ventricular zone neuroblast divisiondefinition[GO:0021847] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.3.12: L-dopachrome 5,6-dihydroxyindole-2-carboxylate.  
1
  • UniProtKB
It requires the following cofactor
 Zn(2+) : Binds 2 Zn(2+) ions per subunit.  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Pigment biosynthesis; melanin biosynthesis  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Melanogenesis  hsa04916+1638  
Metabolic pathways  hsa01100+1638  
Tyrosine metabolism  hsa00350+1638  
 

Keywords

Biological process 
Melanin biosynthesis  definition   [KW-0470]
Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Dopachrome_tautomerase
GenomeRNAi: 1638
PRO: PR:P40126