ADCY8 - Adenylate cyclase type 8 - human protein (Function)
 
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Protein
Gene
References

 
ADCY8 »  Adenylate cyclase type 8   [ EC 4.6.1.1 ]
 
Protein also known as:  Ca(2+)/calmodulin-activated adenylyl cyclase.
Gene name:  ADCY8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).  
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  • UniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
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  • PINC
ATP bindingdefinition[GO:0005524]  
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  • UniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294]  
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  • PINC
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171]  
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  • RefGenome
cAMP-mediated signalingdefinition[GO:0019933]  
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  • RefGenome
Learning or memorydefinition[GO:0007611]  
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  • PINC
Long-term memorydefinition[GO:0007616] silver  
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  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.1: ATP 3',5'-cyclic AMP + diphosphate.  
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  • UniProtKB
It requires the following cofactor
 Mg(2+) : Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).  
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  • UniProtKB
It is regulated in the following manner
Activated by calcium/calmodulin.  
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  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+114  
Calcium signaling pathway  hsa04020+114  
Chemokine signaling pathway  hsa04062+114  
Cholinergic synapse  hsa04725+114  
Dilated cardiomyopathy  hsa05414+114  
GABAergic synapse  hsa04727+114  
Gap junction  hsa04540+114  
Gastric acid secretion  hsa04971+114  
Glutamatergic synapse  hsa04724+114  
GnRH signaling pathway  hsa04912+114  
HTLV-I infection  hsa05166+114  
Long-term potentiation  hsa04720+114  
Melanogenesis  hsa04916+114  
Oocyte meiosis  hsa04114+114  
Pancreatic secretion  hsa04972+114  
Progesterone-mediated oocyte maturation  hsa04914+114  
Purine metabolism  hsa00230+114  
Salivary secretion  hsa04970+114  
Taste transduction  hsa04742+114  
Vascular smooth muscle contraction  hsa04270+114  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  R-HSA-170660  
Adenylate cyclase inhibitory pathway  R-HSA-170670  
CREB phosphorylation through the activation of Adenylate Cyclase  R-HSA-442720  
G alpha (i) signalling events  R-HSA-418594  
G alpha (s) signalling events  R-HSA-418555  
G alpha (z) signalling events  R-HSA-418597  
Glucagon signaling in metabolic regulation  R-HSA-163359  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Hedgehog 'off' state  R-HSA-5610787  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
 

Keywords

Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADCY8
GenomeRNAi: 114
PRO: PR:P40145