ADCY8 - Adenylate cyclase type 8 - human protein (Function)
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ADCY8 »  Adenylate cyclase type 8   [ EC ]
Protein also known as:  Ca(2+)/calmodulin-activated adenylyl cyclase.
Gene name:  ADCY8
Entry whose protein(s) existence is based on evidence at protein level
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This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Adenylate cyclase activitydefinition[GO:0004016]  
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium- and calmodulin-responsive adenylate cyclase activitydefinition[GO:0008294]  
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
GO biological process 
cAMP biosynthetic processdefinition[GO:0006171]  
  • IEAUniProtKB KW
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Learning or memorydefinition[GO:0007611]  
Long-term memorydefinition[GO:0007616] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC ATP 3',5'-cyclic AMP + diphosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 magnesium ions per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by calcium/calmodulin.  
  • CuratedUniProtKB
More information is available from:
According to KEGG, this protein belongs to the following pathways:
Bile secretion  hsa04976+114  
Calcium signaling pathway  hsa04020+114  
Chemokine signaling pathway  hsa04062+114  
Cholinergic synapse  hsa04725+114  
Dilated cardiomyopathy  hsa05414+114  
GABAergic synapse  hsa04727+114  
Gap junction  hsa04540+114  
Gastric acid secretion  hsa04971+114  
Glutamatergic synapse  hsa04724+114  
GnRH signaling pathway  hsa04912+114  
HTLV-I infection  hsa05166+114  
Long-term potentiation  hsa04720+114  
Melanogenesis  hsa04916+114  
Oocyte meiosis  hsa04114+114  
Pancreatic secretion  hsa04972+114  
Progesterone-mediated oocyte maturation  hsa04914+114  
Purine metabolism  hsa00230+114  
Salivary secretion  hsa04970+114  
Taste transduction  hsa04742+114  
Vascular smooth muscle contraction  hsa04270+114  
According to Reactome, this protein belongs to the following pathways:
Adenylate cyclase activating pathway  REACT_15312  
Adenylate cyclase inhibitory pathway  REACT_15333  
CREB phosphorylation through the activation of Adenylate Cyclase  REACT_20625  
G alpha (i) signalling events  REACT_19231  
G alpha (s) signalling events  REACT_19327  
G alpha (z) signalling events  REACT_19333  
Glucagon signaling in metabolic regulation  REACT_1665  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
Regulation of water balance by renal Aquaporins  REACT_24023  


Biological process 
cAMP biosynthesis  definition   [KW-0115]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: ADCY8
GenomeRNAi: 114
PRO: PR:P40145