THPO - Thrombopoietin - human protein (Function)
 
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Protein
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References

 
THPO »  Thrombopoietin
 
Protein also known as:  Myeloproliferative leukemia virus oncogene ligand.
Gene name:  THPO
Family name: EPO/TPO
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 3
GENE REF ISO

Function

 show evidences
Overview 
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
1
  • TASPINC
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
GO biological process 
Cell proliferationdefinition[GO:0008283] silver  
  • IEAInterPro 2 GO
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Myeloid cell differentiationdefinition[GO:0030099] silver  
  • IEAOrtholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
  • ISSOrtholog Curator
Positive regulation of megakaryocyte differentiationdefinition[GO:0045654]  
  • ISSOrtholog Curator
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
  • ISSOrtholog Curator
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
  • ISSOrtholog Curator
Thrombopoietin-mediated signaling pathwaydefinition[GO:0038163]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Hematopoietic cell lineage  hsa04640+7066  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Thrombopoietin
GenomeRNAi: 7066
PRO: PR:P40225