MPL - Thrombopoietin receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
MPL »  Thrombopoietin receptor  (TPO-R)
 
Protein also known as:  Myeloproliferative leukemia protein; CD antigen CD110.
Gene name:  MPL
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 139 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.  
  • CuratedUniProtKB
GO molecular function 
Cytokine receptor activitydefinition[GO:0004896] silver  
  • IEAInterPro 2 GO
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Homeostasis of number of cellsdefinition[GO:0048872] silver  
  • IEAOrtholog Compara
Regulation of chemokine productiondefinition[GO:0032642] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+4352  
Jak-STAT signaling pathway  hsa04630+4352  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
 

Keywords

Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Thrombopoietin_receptor
GenomeRNAi: 4352
PRO: PR:P40238
Chemistry
GuidetoPHARMACOLOGY: 1722