ADH7 - Alcohol dehydrogenase class 4 mu/sigma chain - human protein (Function)
 
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ADH7 »  Alcohol dehydrogenase class 4 mu/sigma chain   [ EC 1.1.1.1 ]
 
Protein also known as:  Alcohol dehydrogenase class IV mu/sigma chain.
Gene name:  ADH7
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

 show evidences
Overview 
Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.  
  • CuratedUniProtKB
GO molecular function 
Alcohol dehydrogenase (NAD) activitydefinition[GO:0004022]  
1
  • TASUniProtKB
Alcohol dehydrogenase activity, zinc-dependentdefinition[GO:0004024]  
1
  • IDAUniProtKB
Aldehyde oxidase activitydefinition[GO:0004031]  
1
  • IDAUniProtKB
Ethanol bindingdefinition[GO:0035276]  
1
  • IDAUniProtKB
Receptor antagonist activitydefinition[GO:0048019]  
1
  • IDAUniProtKB
Retinol bindingdefinition[GO:0019841]  
1
  • IDAUniProtKB
Retinol dehydrogenase activitydefinition[GO:0004745]  
2
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Ethanol catabolic processdefinition[GO:0006068] silver  
  • IEAOrtholog Compara
Ethanol oxidationdefinition[GO:0006069]  
2
  • IDAUniProtKB
Extracellular negative regulation of signal transductiondefinition[GO:1900116]  
1
  • IDAGOC
Fatty acid omega-oxidationdefinition[GO:0010430]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • IDAUniProtKB
Response to bacteriumdefinition[GO:0009617]  
1
  • IDAUniProtKB
Response to ethanoldefinition[GO:0045471]  
1
  • IDAUniProtKB
Retinoic acid metabolic processdefinition[GO:0042573] silver  
  • IEAOrtholog Compara
Retinoid metabolic processdefinition[GO:0001523]  
1
  • IDAUniProtKB
Retinol metabolic processdefinition[GO:0042572] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.1: An alcohol + NAD(+) an aldehyde or ketone + NADH.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Drug metabolism - cytochrome P450  hsa00982+131  
Fatty acid metabolism  hsa00071+131  
Glycolysis / Gluconeogenesis  hsa00010+131  
Metabolic pathways  hsa01100+131  
Metabolism of xenobiotics by cytochrome P450  hsa00980+131  
Retinol metabolism  hsa00830+131  
Tyrosine metabolism  hsa00350+131  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
Note 
There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class-V: ADH6.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADH7
GenomeRNAi: 131
PRO: PR:P40394