PBX1 - Pre-B-cell leukemia transcription factor 1 - human protein (Function)
 
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PBX1 »  Pre-B-cell leukemia transcription factor 1
 
Protein also known as:  Homeobox protein PBX1.
Gene name:  PBX1
Family name: TALE/PBX homeobox
Entry whose protein(s) existence is based on evidence at protein level
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1 67 3
GENE REF ISO

Function

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Overview 
Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation.  
2
  • CuratedUniProtKB
Isoform  PBX1b   As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASPINC
Isoform  PBX1a   Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
  • IEAOrtholog Compara
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Embryonic hemopoiesisdefinition[GO:0035162] silver  
  • IEAOrtholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IEAOrtholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706] silver  
  • IEAOrtholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
  • IEAOrtholog Compara
Isoform  PBX1a   Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • IDAUniProtKB
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of G2/M transition of mitotic cell cycledefinition[GO:0010971] silver  
  • IEAOrtholog Compara
Proximal/distal pattern formationdefinition[GO:0009954] silver  
  • IEAOrtholog Compara
Regulation of ossificationdefinition[GO:0030278] silver  
  • IEAOrtholog Compara
Sex differentiationdefinition[GO:0007548]  
  • IEAUniProtKB KW
Spleen developmentdefinition[GO:0048536] silver  
  • IEAOrtholog Compara
Steroid biosynthetic processdefinition[GO:0006694]  
  • IEAUniProtKB KW
Thymus developmentdefinition[GO:0048538] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Sexual differentiation  definition   [KW-0726]
Steroidogenesis  definition   [KW-0755]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PBX1
GenomeRNAi: 5087
PRO: PR:P40424