STAT3 - Signal transducer and activator of transcription 3 - human protein (Function)
 
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STAT3 »  Signal transducer and activator of transcription 3
 
Protein also known as:  Acute-phase response factor.
Gene name:  STAT3
Entry whose protein(s) existence is based on evidence at protein level
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1 1097 2
GENE REF ISO

Function

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Overview 
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).  
5
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
CCR5 chemokine receptor bindingdefinition[GO:0031730] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
  • ISSOrtholog Curator
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
  • IEAOrtholog Compara
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
32
  • IPIIntAct
  • IPIUniProtKB
Protein dimerization activitydefinition[GO:0046983]  
  • ISSOrtholog Curator
Protein kinase bindingdefinition[GO:0019901]  
  • ISSOrtholog Curator
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • IPIUniProtKB
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • IPIBHF-UCL
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • TASPINC
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAInterPro 2 GO
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
  • IEAOrtholog Compara
Astrocyte differentiationdefinition[GO:0048708]  
  • ISSOrtholog Curator
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • IDABHF-UCL
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • NASUniProtKB
Eating behaviordefinition[GO:0042755]  
  • ISSOrtholog Curator
Eye photoreceptor cell differentiationdefinition[GO:0001754]  
  • ISSOrtholog Curator
Glucose homeostasisdefinition[GO:0042593]  
  • ISSOrtholog Curator
Growth hormone receptor signaling pathwaydefinition[GO:0060396]  
1
  • IDABHF-UCL
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
3
  • IDABHF-UCL
  • IDAUniProtKB
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • IDABHF-UCL
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASUniProtKB
JAK-STAT cascade involved in growth hormone signaling pathwaydefinition[GO:0060397]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Negative regulation of cell deathdefinition[GO:0060548] silver  
  • IEAOrtholog Compara
Negative regulation of neuron migrationdefinition[GO:2001223] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • TASPINC
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Phosphorylationdefinition[GO:0016310]  
  • ISSOrtholog Curator
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Protein import into nucleusdefinition[GO:0006606]  
1
  • IDAUniProtKB
Radial glial cell differentiationdefinition[GO:0060019]  
  • ISSOrtholog Curator
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
  • IEAOrtholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355]  
1
  • IDABHF-UCL
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Sexual reproductiondefinition[GO:0019953]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
2
  • TASPINC
Stem cell maintenancedefinition[GO:0019827] silver  
  • IEAOrtholog Compara
Temperature homeostasisdefinition[GO:0001659]  
  • ISSOrtholog Curator
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+6774  
Adipocytokine signaling pathway  hsa04920+6774  
Chemokine signaling pathway  hsa04062+6774  
Hepatitis C  hsa05160+6774  
Jak-STAT signaling pathway  hsa04630+6774  
Measles  hsa05162+6774  
Pancreatic cancer  hsa05212+6774  
Pathways in cancer  hsa05200+6774  
Toxoplasmosis  hsa05145+6774  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
Note 
Involved in the gp130-mediated signaling pathway.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STAT3
GenomeRNAi: 6774
PRO: PR:P40763