STAT3 - Signal transducer and activator of transcription 3 - human protein (Function)
 
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STAT3 »  Signal transducer and activator of transcription 3
 
Protein also known as:  Acute-phase response factor.
Gene name:  STAT3
Entry whose protein(s) existence is based on evidence at protein level
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1 1660 3
GENE REF ISO

Function

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Overview 
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).  
6
  • UniProtKB
GO molecular function 
CCR5 chemokine receptor bindingdefinition[GO:0031730] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • Ortholog Curator
Glucocorticoid receptor bindingdefinition[GO:0035259] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
40
  • IntAct
  • UniProtKB
Protein dimerization activitydefinition[GO:0046983]  
1
  • Ortholog Curator
Protein kinase bindingdefinition[GO:0019901]  
1
  • Ortholog Curator
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • BHF-UCL
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • BHF-UCL
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingdefinition[GO:0004879]  
1
  • BHF-UCL
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
2
  • PINC
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • BHF-UCL
Transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingdefinition[GO:0001077]  
1
  • BHF-UCL
Transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingdefinition[GO:0001228]  
1
  • BHF-UCL
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
1
  • Ortholog Compara
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Astrocyte differentiationdefinition[GO:0048708]  
1
  • Ortholog Curator
Cell proliferationdefinition[GO:0008283] silver  
1
  • Ortholog Compara
Cellular response to hormone stimulusdefinition[GO:0032870]  
1
  • BHF-UCL
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • UniProtKB
Eating behaviordefinition[GO:0042755]  
1
  • Ortholog Curator
Eye photoreceptor cell differentiationdefinition[GO:0001754]  
1
  • Ortholog Curator
Glucose homeostasisdefinition[GO:0042593]  
1
  • Ortholog Curator
Growth hormone receptor signaling pathwaydefinition[GO:0060396]  
1
  • BHF-UCL
Interleukin-6-mediated signaling pathwaydefinition[GO:0070102]  
5
  • BHF-UCL
  • UniProtKB
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • BHF-UCL
JAK-STAT cascadedefinition[GO:0007259]  
1
  • UniProtKB
JAK-STAT cascade involved in growth hormone signaling pathwaydefinition[GO:0060397]  
2
  • BHF-UCL
  • Ortholog Curator
Movement of cell or subcellular componentdefinition[GO:0006928]  
1
  • PINC
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • CACAO
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of glycolytic processdefinition[GO:0045820] silver  
1
  • Ortholog Compara
Negative regulation of hydrogen peroxide biosynthetic processdefinition[GO:0010730] silver  
1
  • Ortholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
1
  • Ortholog Compara
Negative regulation of neuron migrationdefinition[GO:2001223] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • PINC
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Phosphorylationdefinition[GO:0016310]  
1
  • Ortholog Curator
Positive regulation of ATP biosynthetic processdefinition[GO:2001171] silver  
1
  • Ortholog Compara
Positive regulation of growth factor dependent skeletal muscle satellite cell proliferationdefinition[GO:1902728] silver  
1
  • Ortholog Compara
Positive regulation of Notch signaling pathwaydefinition[GO:0045747]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
4
  • GO_central
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • CACAO
  • Ortholog Curator
Protein import into nucleusdefinition[GO:0006606]  
1
  • UniProtKB
Radial glial cell differentiationdefinition[GO:0060019]  
1
  • Ortholog Curator
Regulation of mitochondrial membrane permeabilitydefinition[GO:0046902] silver  
1
  • Ortholog Compara
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
1
  • Ortholog Compara
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • Ortholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355]  
1
  • BHF-UCL
Response to ethanoldefinition[GO:0045471] silver  
1
  • Ortholog Compara
Sexual reproductiondefinition[GO:0019953]  
1
  • Ortholog Curator
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Temperature homeostasisdefinition[GO:0001659]  
1
  • Ortholog Curator
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Acute myeloid leukemia  hsa05221+6774  
Adipocytokine signaling pathway  hsa04920+6774  
Chemokine signaling pathway  hsa04062+6774  
Hepatitis C  hsa05160+6774  
Jak-STAT signaling pathway  hsa04630+6774  
Measles  hsa05162+6774  
Pancreatic cancer  hsa05212+6774  
Pathways in cancer  hsa05200+6774  
Toxoplasmosis  hsa05145+6774  
According to Reactome, this protein belongs to the following pathways:
Downstream signal transduction  R-HSA-186763  
Growth hormone receptor signaling  R-HSA-982772  
Interleukin-6 signaling  R-HSA-1059683  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  R-HSA-2892247  
Senescence-Associated Secretory Phenotype (SASP)  R-HSA-2559582  
Signaling by FGFR1 fusion mutants  R-HSA-1839117  
Signaling by Leptin  R-HSA-2586552  
Signaling by SCF-KIT  R-HSA-1433557  
Signalling to STAT3  R-HSA-198745  
Transcriptional regulation of pluripotent stem cells  R-HSA-452723  
Note 
Involved in the gp130-mediated signaling pathway.  
1
  • UniProtKB
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STAT3
GenomeRNAi: 6774
PRO: PR:P40763