SLC26A3 - Chloride anion exchanger - human protein (Function)
 
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Protein
Gene
References

 
SLC26A3 »  Chloride anion exchanger
 
Protein also known as:  Solute carrier family 26 member 3.
Gene name:  SLC26A3
Entry whose protein(s) existence is based on evidence at protein level
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1 55 1
GENE REF ISO

Function

 show evidences
Overview 
Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the sulfate permease (sulp) family  2.A.53.2.18  
GO molecular function 
Anion:anion antiporter activitydefinition[GO:0015301] silver  
  • IEAOrtholog Compara
Bicarbonate transmembrane transporter activitydefinition[GO:0015106]  
  • ISSOrtholog Curator
Chloride transmembrane transporter activitydefinition[GO:0015108]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Secondary active sulfate transmembrane transporter activitydefinition[GO:0008271] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription cofactor activitydefinition[GO:0003712]  
1
  • TASPINC
Transporter activitydefinition[GO:0005215]  
1
  • TASPINC
GO biological process 
Anion transportdefinition[GO:0006820]  
1
  • TASPINC
Bicarbonate transportdefinition[GO:0015701] silver  
  • IEAOrtholog Compara
Cellular response to cAMPdefinition[GO:0071320]  
  • ISSOrtholog Curator
Chloride transmembrane transportdefinition[GO:1902476]  
  • IEAOrtholog Compara
  • ISSOrtholog Curator
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Intracellular pH elevationdefinition[GO:0051454]  
  • ISSOrtholog Curator
Membrane hyperpolarizationdefinition[GO:0060081]  
  • ISSOrtholog Curator
Regulation of RNA biosynthetic processdefinition[GO:2001141]  
1
  • TASGOC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • TASGOC
Sperm capacitationdefinition[GO:0048240]  
  • ISSOrtholog Curator
Sulfate transmembrane transportdefinition[GO:1902358]  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Mineral absorption  hsa04978+1811  
Pancreatic secretion  hsa04972+1811  
According to Reactome, this protein belongs to the following pathway:
Multifunctional anion exchangers  REACT_19357  
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC26A3
GenomeRNAi: 1811
PRO: PR:P40879