SLC26A3 - Chloride anion exchanger - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SLC26A3 »  Chloride anion exchanger
 
Protein also known as:  Solute carrier family 26 member 3.
Gene name:  SLC26A3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 1
GENE REF ISO

Function

 show evidences
Overview 
Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the sulfate permease (sulp) family  2.A.53.2.18  
GO molecular function 
Anion:anion antiporter activitydefinition[GO:0015301]  
1
  • RefGenome
Bicarbonate transmembrane transporter activitydefinition[GO:0015106]  
2
  • Ortholog Curator
  • RefGenome
Chloride channel activitydefinition[GO:0005254]  
1
  • RefGenome
Chloride transmembrane transporter activitydefinition[GO:0015108]  
1
  • Ortholog Curator
Oxalate transmembrane transporter activitydefinition[GO:0019531]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Secondary active sulfate transmembrane transporter activitydefinition[GO:0008271] silver  
1
  • InterPro 2 GO
Sulfate transmembrane transporter activitydefinition[GO:0015116]  
1
  • RefGenome
Transcription cofactor activitydefinition[GO:0003712]  
1
  • PINC
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Anion transportdefinition[GO:0006820]  
1
  • PINC
Bicarbonate transportdefinition[GO:0015701]  
1
  • RefGenome
Cellular response to cAMPdefinition[GO:0071320]  
1
  • Ortholog Curator
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • RefGenome
Excretiondefinition[GO:0007588]  
1
  • PINC
Intracellular pH elevationdefinition[GO:0051454]  
1
  • Ortholog Curator
Membrane hyperpolarizationdefinition[GO:0060081]  
1
  • Ortholog Curator
Oxalate transportdefinition[GO:0019532]  
1
  • RefGenome
Regulation of intracellular pHdefinition[GO:0051453]  
1
  • RefGenome
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • RefGenome
Regulation of nucleic acid-templated transcriptiondefinition[GO:1903506]  
1
  • GOC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • GOC
Sperm capacitationdefinition[GO:0048240]  
1
  • Ortholog Curator
Sulfate transmembrane transportdefinition[GO:1902358]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Mineral absorption  hsa04978+1811  
Pancreatic secretion  hsa04972+1811  
According to Reactome, this protein belongs to the following pathways:
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)  R-HSA-5619085  
Multifunctional anion exchangers  R-HSA-427601  
 

Keywords

Biological process 
Antiport  definition   [KW-0050]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC26A3
GenomeRNAi: 1811
PRO: PR:P40879