MDH2 - Malate dehydrogenase, mitochondrial - human protein (Function)
 
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Protein
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References

 
MDH2 »  Malate dehydrogenase, mitochondrial   [ EC 1.1.1.37 ]
 
Gene name:  MDH2
Family name: LDH/MDH » MDH type 1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
L-malate dehydrogenase activitydefinition[GO:0030060]  
2
  • IDAUniProtKB
Malate dehydrogenase (NADP+) activitydefinition[GO:0046554] silver  
  • IEAOrtholog Compara
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular carbohydrate metabolic processdefinition[GO:0044262] silver  
  • IEAInterPro 2 GO
Internal protein amino acid acetylationdefinition[GO:0006475]  
1
  • IDAUniProtKB
Malate metabolic processdefinition[GO:0006108]  
2
  • IDAUniProtKB
NADH metabolic processdefinition[GO:0006734] silver  
  • IEAOrtholog Compara
Oxaloacetate metabolic processdefinition[GO:0006107] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.1.1.37: (S)-malate + NAD(+) oxaloacetate + NADH.  
  • CuratedUniProtKB
It is regulated in the following manner
Enzyme activity is enhanced by acetylation.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+4191  
Glyoxylate and dicarboxylate metabolism  hsa00630+4191  
Metabolic pathways  hsa01100+4191  
Pyruvate metabolism  hsa00620+4191  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Malate_dehydrogenase_2
GenomeRNAi: 4191
PRO: PR:P40926