HADHA - Trifunctional enzyme subunit alpha, mitochondrial - human protein (Function)
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HADHA »  Trifunctional enzyme subunit alpha, mitochondrial
Protein also known as:  78 kDa gastrin-binding protein.
Gene name:  HADHA
Family names: In the central section 3-hydroxyacyl-CoA dehydrogenase
In the N-terminal section Enoyl-CoA hydratase/isomerase
Entry whose protein(s) existence is based on evidence at protein level
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1 55 2


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Bifunctional subunit.  
  • CuratedUniProtKB
GO molecular function 
3-hydroxyacyl-CoA dehydrogenase activitydefinition[GO:0003857]  
Acetyl-CoA C-acetyltransferase activitydefinition[GO:0003985]  
Enoyl-CoA hydratase activitydefinition[GO:0004300]  
  • IEAEC 2 GO
Fatty-acyl-CoA bindingdefinition[GO:0000062] silver  
  • IEAOrtholog Compara
Long-chain-3-hydroxyacyl-CoA dehydrogenase activitydefinition[GO:0016509]  
  • IEAEC 2 GO
Long-chain-enoyl-CoA hydratase activitydefinition[GO:0016508] silver  
  • IEAOrtholog Compara
NAD bindingdefinition[GO:0051287] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
GO biological process 
Fatty acid beta-oxidationdefinition[GO:0006635]  
  • IEAUniPathway
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC (3S)-3-hydroxyacyl-CoA trans-2(or 3)-enoyl-CoA + H(2)O.  
  • CuratedUniProtKB
EC A long-chain (S)-3-hydroxyacyl-CoA + NAD(+) a long-chain 3-oxoacyl-CoA + NADH.  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
beta-Alanine metabolism  hsa00410+3030  
Biosynthesis of unsaturated fatty acids  hsa01040+3030  
Butanoate metabolism  hsa00650+3030  
Fatty acid elongation  hsa00062+3030  
Fatty acid metabolism  hsa00071+3030  
Lysine degradation  hsa00310+3030  
Metabolic pathways  hsa01100+3030  
Propanoate metabolism  hsa00640+3030  
Tryptophan metabolism  hsa00380+3030  
Valine, leucine and isoleucine degradation  hsa00280+3030  
According to Reactome, this protein belongs to the following pathways:
Acyl chain remodeling of CL  REACT_121006  
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA  REACT_1708  
Beta oxidation of hexanoyl-CoA to butanoyl-CoA  REACT_1887  
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA  REACT_735  
Beta oxidation of myristoyl-CoA to lauroyl-CoA  REACT_2108  
Beta oxidation of octanoyl-CoA to hexanoyl-CoA  REACT_1697  
Beta oxidation of palmitoyl-CoA to myristoyl-CoA  REACT_2025  
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids  REACT_160  
More information is available from:


Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Lyase  definition   [KW-0456]
Oxidoreductase  definition   [KW-0560]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]

Further external links

Enzyme and pathway databases
SABIO-RK: P40939
GenomeRNAi: 3030
PRO: PR:P40939