OPRD1 - Delta-type opioid receptor - human protein (Function)
 
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OPRD1 »  Delta-type opioid receptor  (DOR-1)
 
Gene name:  OPRD1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 63 1
GENE REF ISO

Function

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Overview 
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.  
3
  • CuratedUniProtKB
GO molecular function 
Enkephalin receptor activitydefinition[GO:0038046]  
1
  • IMPUniProtKB
Opioid receptor activitydefinition[GO:0004985]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Adult locomotory behaviordefinition[GO:0008344] silver  
  • IEAOrtholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAUniProtKB
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
  • IEAOrtholog Compara
Opioid receptor signaling pathwaydefinition[GO:0038003]  
1
  • IMPUniProtKB
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
  • ISSOrtholog Curator
Protein import into nucleus, translocationdefinition[GO:0000060]  
1
  • IDAUniProtKB
Regulation of calcium ion transportdefinition[GO:0051924] silver  
  • IEAOrtholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+4985  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: %CE%94-opioid_receptor
GenomeRNAi: 4985
PRO: PR:P41143
Chemistry
GuidetoPHARMACOLOGY: 317