OPRL1 - Nociceptin receptor - human protein (Function)
 
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OPRL1 »  Nociceptin receptor
 
Gene name:  OPRL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 2
GENE REF ISO

Function

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Overview 
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.  
5
  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
2
  • IGIUniProtKB
Nociceptin receptor activitydefinition[GO:0001626]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
2
  • IMPUniProtKB
Behaviordefinition[GO:0007610]  
  • IEAUniProtKB KW
Opioid receptor signaling pathwaydefinition[GO:0038003]  
1
  • IDAGOC
  • IEAInterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IGIUniProtKB
Sensory perceptiondefinition[GO:0007600]  
1
  • TASPINC
Sensory perception of paindefinition[GO:0019233]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+4987  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Nociceptin_receptor
GenomeRNAi: 4987
PRO: PR:P41146
Chemistry
GuidetoPHARMACOLOGY: 320