OPRL1 - Nociceptin receptor - human protein (Function)
 
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OPRL1 »  Nociceptin receptor
 
Protein also known as:  Kappa-type 3 opioid receptor (KOR-3).
Gene name:  OPRL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 53 2
GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.  
6
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
2
  • UniProtKB
Neuropeptide bindingdefinition[GO:0042923]  
1
  • RefGenome
Nociceptin receptor activitydefinition[GO:0001626]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
GO biological process 
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193]  
2
  • UniProtKB
Eating behaviordefinition[GO:0042755] silver  
1
  • Ortholog Compara
Estrous cycledefinition[GO:0044849] silver  
1
  • Ortholog Compara
Locomotor rhythmdefinition[GO:0045475] silver  
1
  • Ortholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
1
  • Ortholog Compara
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818] silver  
1
  • Ortholog Compara
Negative regulation of voltage-gated calcium channel activitydefinition[GO:1901386] silver  
1
  • Ortholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • RefGenome
Opioid receptor signaling pathwaydefinition[GO:0038003]  
2
  • GOC
  • InterPro 2 GO
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • UniProtKB
Positive regulation of gastric acid secretiondefinition[GO:0060454] silver  
1
  • Ortholog Compara
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • Ortholog Compara
Positive regulation of urine volumedefinition[GO:0035810] silver  
1
  • Ortholog Compara
Regulation of sensory perception of paindefinition[GO:0051930] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Sensory perceptiondefinition[GO:0007600]  
1
  • PINC
Sensory perception of paindefinition[GO:0019233]  
2
  • Ortholog Curator
  • RefGenome
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+4987  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  R-HSA-418594  
Peptide ligand-binding receptors  R-HSA-375276  
 

Keywords

Biological process 
Behavior  definition   [KW-0085]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Nociceptin_receptor
GenomeRNAi: 4987
PRO: PR:P41146
Chemistry
GuidetoPHARMACOLOGY: 320