LEP - Leptin - human protein (Function)
 
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LEP »  Leptin
 
Protein also known as:  Obesity factor.
Gene name:  LEP
Family name: Leptin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.  
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083] silver  
  • IEAOrtholog Compara
Hormone activitydefinition[GO:0005179] silver  
  • IEAOrtholog Compara
Peptide hormone receptor bindingdefinition[GO:0051428] silver  
  • IEAOrtholog Compara
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
  • IEAOrtholog Compara
Adult feeding behaviordefinition[GO:0008343]  
  • ISSOrtholog Curator
Bile acid metabolic processdefinition[GO:0008206] silver  
  • IEAOrtholog Compara
Bone mineralization involved in bone maturationdefinition[GO:0035630] silver  
  • IEAOrtholog Compara
Cellular response to L-ascorbic aciddefinition[GO:0071298] silver  
  • IEAOrtholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
  • IEAOrtholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
  • IEAOrtholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
  • IEAOrtholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Eating behaviordefinition[GO:0042755] silver  
  • IEAOrtholog Compara
Energy reserve metabolic processdefinition[GO:0006112] silver  
  • IEAOrtholog Compara
Fatty acid catabolic processdefinition[GO:0009062] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Glucose metabolic processdefinition[GO:0006006] silver  
  • IEAOrtholog Compara
Glycerol biosynthetic processdefinition[GO:0006114] silver  
  • IEAOrtholog Compara
Hormone metabolic processdefinition[GO:0042445] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Leptin-mediated signaling pathwaydefinition[GO:0033210] silver  
  • IEAOrtholog Compara
Leukocyte tethering or rollingdefinition[GO:0050901] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of appetitedefinition[GO:0032099]  
  • ISSOrtholog Curator
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
  • IEAOrtholog Compara
Negative regulation of glucagon secretiondefinition[GO:0070093] silver  
  • IEAOrtholog Compara
Negative regulation of glutamine transportdefinition[GO:2000486] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Negative regulation of vasoconstrictiondefinition[GO:0045906] silver  
  • IEAOrtholog Compara
Ovulation from ovarian follicledefinition[GO:0001542] silver  
  • IEAOrtholog Compara
Placenta developmentdefinition[GO:0001890]  
1
  • IDADFLAT
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytokine productiondefinition[GO:0001819] silver  
  • IEAOrtholog Compara
Positive regulation of developmental growthdefinition[GO:0048639]  
1
  • IDADFLAT
Positive regulation of follicle-stimulating hormone secretiondefinition[GO:0046881] silver  
  • IEAOrtholog Compara
Positive regulation of hepatic stellate cell activationdefinition[GO:2000491] silver  
  • IEAOrtholog Compara
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628] silver  
  • IEAOrtholog Compara
Positive regulation of ion transportdefinition[GO:0043270] silver  
  • IEAOrtholog Compara
Positive regulation of luteinizing hormone secretiondefinition[GO:0033686] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
  • IEAOrtholog Compara
Positive regulation of myeloid cell differentiationdefinition[GO:0045639] silver  
  • IEAOrtholog Compara
Positive regulation of STAT protein import into nucleusdefinition[GO:2000366] silver  
  • IEAOrtholog Compara
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517] silver  
  • IEAOrtholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
  • IEAOrtholog Compara
Regulation of fat cell differentiationdefinition[GO:0045598] silver  
  • IEAOrtholog Compara
Regulation of gluconeogenesisdefinition[GO:0006111] silver  
  • IEAOrtholog Compara
Regulation of insulin secretiondefinition[GO:0050796] silver  
  • IEAOrtholog Compara
Regulation of intestinal cholesterol absorptiondefinition[GO:0030300] silver  
  • IEAOrtholog Compara
Regulation of lipoprotein lipid oxidationdefinition[GO:0060587] silver  
  • IEAOrtholog Compara
Regulation of steroid biosynthetic processdefinition[GO:0050810] silver  
  • IEAOrtholog Compara
Response to dietary excessdefinition[GO:0002021] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to vitamin Edefinition[GO:0033197] silver  
  • IEAOrtholog Compara
Tyrosine phosphorylation of STAT proteindefinition[GO:0007260] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+3952  
Cytokine-cytokine receptor interaction  hsa04060+3952  
Jak-STAT signaling pathway  hsa04630+3952  
Neuroactive ligand-receptor interaction  hsa04080+3952  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Leptin
GenomeRNAi: 3952
PRO: PR:P41159