LEP - Leptin - human protein (Function)
 
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LEP »  Leptin
 
Protein also known as:  Obesity factor.
Gene name:  LEP
Family name: Leptin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.  
1
  • UniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083] silver  
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  • Ortholog Compara
Hormone activitydefinition[GO:0005179] silver  
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  • InterPro 2 GO
Peptide hormone receptor bindingdefinition[GO:0051428] silver  
1
  • Ortholog Compara
GO biological process 
Adipose tissue developmentdefinition[GO:0060612] silver  
1
  • Ortholog Compara
Adult feeding behaviordefinition[GO:0008343]  
1
  • Ortholog Curator
Bile acid metabolic processdefinition[GO:0008206] silver  
1
  • Ortholog Compara
Bone mineralization involved in bone maturationdefinition[GO:0035630] silver  
1
  • Ortholog Compara
Cellular response to L-ascorbic aciddefinition[GO:0071298] silver  
1
  • Ortholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
1
  • Ortholog Compara
Central nervous system neuron developmentdefinition[GO:0021954] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Eating behaviordefinition[GO:0042755] silver  
1
  • Ortholog Compara
Energy reserve metabolic processdefinition[GO:0006112] silver  
1
  • Ortholog Compara
Fatty acid beta-oxidationdefinition[GO:0006635] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
Glucose homeostasisdefinition[GO:0042593] silver  
1
  • Ortholog Compara
Glucose metabolic processdefinition[GO:0006006] silver  
1
  • Ortholog Compara
Glycerol biosynthetic processdefinition[GO:0006114] silver  
1
  • Ortholog Compara
Hormone metabolic processdefinition[GO:0042445] silver  
1
  • Ortholog Compara
Insulin secretiondefinition[GO:0030073] silver  
1
  • Ortholog Compara
Leptin-mediated signaling pathwaydefinition[GO:0033210] silver  
1
  • Ortholog Compara
Leukocyte tethering or rollingdefinition[GO:0050901] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Negative regulation of appetitedefinition[GO:0032099]  
1
  • Ortholog Curator
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
1
  • Ortholog Compara
Negative regulation of glucagon secretiondefinition[GO:0070093] silver  
1
  • Ortholog Compara
Negative regulation of glutamine transportdefinition[GO:2000486] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Negative regulation of vasoconstrictiondefinition[GO:0045906] silver  
1
  • Ortholog Compara
Ovulation from ovarian follicledefinition[GO:0001542] silver  
1
  • Ortholog Compara
Placenta developmentdefinition[GO:0001890]  
1
  • DFLAT
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of cytokine productiondefinition[GO:0001819] silver  
1
  • Ortholog Compara
Positive regulation of developmental growthdefinition[GO:0048639]  
1
  • DFLAT
Positive regulation of follicle-stimulating hormone secretiondefinition[GO:0046881] silver  
1
  • Ortholog Compara
Positive regulation of hepatic stellate cell activationdefinition[GO:2000491] silver  
1
  • Ortholog Compara
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628] silver  
1
  • Ortholog Compara
Positive regulation of ion transportdefinition[GO:0043270] silver  
1
  • Ortholog Compara
Positive regulation of luteinizing hormone secretiondefinition[GO:0033686] silver  
1
  • Ortholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
1
  • Ortholog Compara
Positive regulation of myeloid cell differentiationdefinition[GO:0045639] silver  
1
  • Ortholog Compara
Positive regulation of STAT protein import into nucleusdefinition[GO:2000366] silver  
1
  • Ortholog Compara
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517] silver  
1
  • Ortholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
1
  • Ortholog Compara
Regulation of fat cell differentiationdefinition[GO:0045598] silver  
1
  • Ortholog Compara
Regulation of gluconeogenesisdefinition[GO:0006111] silver  
1
  • Ortholog Compara
Regulation of insulin secretiondefinition[GO:0050796] silver  
1
  • Ortholog Compara
Regulation of intestinal cholesterol absorptiondefinition[GO:0030300] silver  
1
  • Ortholog Compara
Regulation of lipoprotein lipid oxidationdefinition[GO:0060587] silver  
1
  • Ortholog Compara
Regulation of steroid biosynthetic processdefinition[GO:0050810] silver  
1
  • Ortholog Compara
Response to dietary excessdefinition[GO:0002021] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to vitamin Edefinition[GO:0033197] silver  
1
  • Ortholog Compara
Tyrosine phosphorylation of STAT proteindefinition[GO:0007260] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+3952  
Cytokine-cytokine receptor interaction  hsa04060+3952  
Jak-STAT signaling pathway  hsa04630+3952  
Neuroactive ligand-receptor interaction  hsa04080+3952  
According to Reactome, this protein belongs to the following pathways:
Signaling by Leptin  REACT_169118  
Synthesis, secretion, and deacylation of Ghrelin  REACT_19189  
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)  REACT_24019  
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Leptin
GenomeRNAi: 3952
PRO: PR:P41159