CASR - Extracellular calcium-sensing receptor - human protein (Function)
 
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CASR »  Extracellular calcium-sensing receptor
 
Gene name:  CASR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.7.2  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • TASPINC
Calcium ion importdefinition[GO:0070509]  
1
  • IDAUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • TASPINC
Chemosensory behaviordefinition[GO:0007635]  
1
  • TASPINC
Detection of calcium iondefinition[GO:0005513]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
  • IEAUniProtKB KW
Metabolic processdefinition[GO:0008152]  
1
  • TASGOC
Ossificationdefinition[GO:0001503]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Class C/3 (Metabotropic glutamate/pheromone receptors)  REACT_18319  
G alpha (i) signalling events  REACT_19231  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Calcium-sensing_receptor
GenomeRNAi: 846
PRO: PR:P41180
Chemistry
GuidetoPHARMACOLOGY: 54