AQP2 - Aquaporin-2 - human protein (Function)
 
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AQP2 »  Aquaporin-2  (AQP-2)
 
Protein also known as:  Water channel protein for renal collecting duct.
Gene name:  AQP2
Entry whose protein(s) existence is based on evidence at protein level
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1 112 1
GENE REF ISO

Function

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Overview 
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the major intrinsic protein (mip) family  1.A.8.8.8  
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAOrtholog Compara
Glycerol transmembrane transporter activitydefinition[GO:0015168]  
1
  • IDAUniProtKB
PDZ domain bindingdefinition[GO:0030165] silver  
  • IEAOrtholog Compara
Water transmembrane transporter activitydefinition[GO:0005372]  
2
  • IDAUniProtKB
GO biological process 
Actin filament depolymerizationdefinition[GO:0030042] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915] silver  
  • IEAOrtholog Compara
Cell volume homeostasisdefinition[GO:0006884] silver  
  • IEAOrtholog Compara
Cellular response to copper iondefinition[GO:0071280]  
1
  • IDAUniProtKB
Cellular response to mercury iondefinition[GO:0071288]  
1
  • IDAUniProtKB
Cellular response to water deprivationdefinition[GO:0042631] silver  
  • IEAOrtholog Compara
Excretiondefinition[GO:0007588]  
1
  • TASPINC
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
Glycerol transportdefinition[GO:0015793]  
1
  • IDAUniProtKB
Hyperosmotic responsedefinition[GO:0006972] silver  
  • IEAOrtholog Compara
Metanephric collecting duct developmentdefinition[GO:0072205] silver  
  • IEAOrtholog Compara
Positive regulation of calcium ion transportdefinition[GO:0051928] silver  
  • IEAOrtholog Compara
Renal water transportdefinition[GO:0003097] silver  
  • IEAOrtholog Compara
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Response to glucagondefinition[GO:0033762] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to lithium iondefinition[GO:0010226] silver  
  • IEAOrtholog Compara
Response to salt stressdefinition[GO:0009651] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Water transportdefinition[GO:0006833]  
2
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vasopressin-regulated water reabsorption  hsa04962+359  
According to Reactome, this protein belongs to the following pathways:
Passive transport by Aquaporins  REACT_23826  
Regulation of water balance by renal Aquaporins  REACT_24023  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Aquaporin_2
GenomeRNAi: 359
PRO: PR:P41181
Chemistry
GuidetoPHARMACOLOGY: 689