CETN2 - Centrin-2 - human protein (Function)
 
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Protein
Gene
References

 
CETN2 »  Centrin-2
 
Protein also known as:  Caltractin isoform 1.
Gene name:  CETN2
Family name: Centrin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 55 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.  
6
  • CuratedUniProtKB
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.  
6
  • CuratedUniProtKB
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.  
6
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAInterPro 2 GO
ATP-dependent helicase activitydefinition[GO:0008026] silver  
  • IEAInterPro 2 GO
Calcium ion bindingdefinition[GO:0005509]  
1
  • NASUniProtKB
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
  • IEAOrtholog Compara
Heterotrimeric G-protein bindingdefinition[GO:0032795] silver  
  • IEAOrtholog Compara
Microtubule bindingdefinition[GO:0008017] silver  
  • IEAOrtholog Compara
Nucleic acid bindingdefinition[GO:0003676] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
GO biological process 
Centriole replicationdefinition[GO:0007099]  
1
  • IMPUniProtKB
Mitosisdefinition[GO:0007067]  
1
  • NASUniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • IDAUniProtKB
Regulation of cytokinesisdefinition[GO:0032465]  
1
  • IMPUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nucleotide excision repair  hsa03420+1069  
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CETN2
GenomeRNAi: 1069
PRO: PR:P41208