CETN2 - Centrin-2 - human protein (Function)
 
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Protein
Gene
References

 
CETN2 »  Centrin-2
 
Protein also known as:  Caltractin isoform 1.
Gene name:  CETN2
Family name: Centrin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.  
1
  • UniProtKB
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.  
1
  • UniProtKB
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.  
1
  • UniProtKB
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed22307388).  
2
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
G-protein beta/gamma-subunit complex bindingdefinition[GO:0031683] silver  
1
  • Ortholog Compara
Heterotrimeric G-protein bindingdefinition[GO:0032795] silver  
1
  • Ortholog Compara
Microtubule bindingdefinition[GO:0008017] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
GO biological process 
Cell divisiondefinition[GO:0051301]  
1
  • UniProtKB KW
Centriole replicationdefinition[GO:0007099]  
1
  • UniProtKB
Mitotic nuclear divisiondefinition[GO:0007067]  
1
  • UniProtKB
Nucleotide-excision repairdefinition[GO:0006289]  
1
  • UniProtKB
Regulation of cytokinesisdefinition[GO:0032465]  
1
  • UniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nucleotide excision repair  hsa03420+1069  
According to Reactome, this protein belongs to the following pathways:
Anchoring of the basal body to the plasma membrane  REACT_267965  
Loss of Nlp from mitotic centrosomes  REACT_15364  
Loss of proteins required for interphase microtubule organization from the centrosome  REACT_15451  
Recruitment of mitotic centrosome proteins and complexes  REACT_15296  
Regulation of PLK1 Activity at G2/M Transition  REACT_160315  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Mitosis  definition   [KW-0498]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: CETN2
GenomeRNAi: 1069
PRO: PR:P41208