RGS2 - Regulator of G-protein signaling 2 - human protein (Function)
 
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RGS2 »  Regulator of G-protein signaling 2  (RGS2)
 
Protein also known as:  Cell growth-inhibiting gene 31 protein.
Gene name:  RGS2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.  
5
  • UniProtKB
GO molecular function 
Beta-tubulin bindingdefinition[GO:0048487] silver  
1
  • Ortholog Compara
Calmodulin bindingdefinition[GO:0005516]  
1
  • PINC
GTPase activator activitydefinition[GO:0005096]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
  • UniProtKB
GO biological process 
Brown fat cell differentiationdefinition[GO:0050873] silver  
1
  • Ortholog Compara
Cell cycledefinition[GO:0007049]  
1
  • UniProtKB KW
Negative regulation of cAMP-mediated signalingdefinition[GO:0043951] silver  
1
  • Ortholog Compara
Negative regulation of cardiac muscle hypertrophydefinition[GO:0010614]  
1
  • Ortholog Curator
Negative regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0045744]  
1
  • Ortholog Curator
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
1
  • Ortholog Curator
Negative regulation of phospholipase activitydefinition[GO:0010519]  
1
  • Ortholog Curator
Positive regulation of cardiac muscle contractiondefinition[GO:0060452]  
1
  • Ortholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547] silver  
1
  • Ortholog Compara
Positive regulation of microtubule polymerizationdefinition[GO:0031116] silver  
1
  • Ortholog Compara
Regulation of adrenergic receptor signaling pathwaydefinition[GO:0071877]  
1
  • Ortholog Curator
Regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0008277]  
1
  • PINC
Regulation of translationdefinition[GO:0006417]  
1
  • UniProtKB KW
Relaxation of cardiac muscledefinition[GO:0055119]  
1
  • Ortholog Curator
Relaxation of vascular smooth muscledefinition[GO:0060087] silver  
1
  • Ortholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
1
  • Ortholog Compara
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
1
  • InterPro 2 GO
Pathways 
According to Reactome, this protein belongs to the following pathway:
G alpha (q) signalling events  REACT_18283  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Translation regulation  definition   [KW-0810]
Molecular function 
Signal transduction inhibitor  definition   [KW-0734]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RGS2
GenomeRNAi: 5997
PRO: PR:P41220