WNT5A - Protein Wnt-5a - human protein (Function)
 
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WNT5A »  Protein Wnt-5a
 
Gene name:  WNT5A
Family name: Wnt
Entry whose protein(s) existence is based on evidence at protein level
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1 191 2
GENE REF ISO

Function

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Overview 
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.  
3
  • UniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125] silver  
1
  • Ortholog Compara
Frizzled bindingdefinition[GO:0005109]  
1
  • UniProtKB
Frizzled-2 bindingdefinition[GO:0005110] silver  
1
  • Ortholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Receptor agonist activitydefinition[GO:0048018]  
1
  • BHF-UCL
Receptor tyrosine kinase-like orphan receptor bindingdefinition[GO:0005115]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
2
  • BHF-UCL
Activation of MAPK activitydefinition[GO:0000187]  
1
  • BHF-UCL
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • BHF-UCL
Ameboidal-type cell migrationdefinition[GO:0001667] silver  
1
  • Ortholog Compara
Anterior/posterior axis specification, embryodefinition[GO:0008595] silver  
1
  • Ortholog Compara
Axon guidancedefinition[GO:0007411]  
1
  • Ortholog Curator
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
1
  • Ortholog Compara
Cartilage developmentdefinition[GO:0051216]  
1
  • UniProtKB KW
Cell fate commitmentdefinition[GO:0045165]  
1
  • RefGenome
Cellular protein localizationdefinition[GO:0034613]  
1
  • UniProtKB
Cellular response to calcium iondefinition[GO:0071277]  
1
  • UniProtKB
Cellular response to interferon-gammadefinition[GO:0071346]  
1
  • UniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • UniProtKB
Cellular response to retinoic aciddefinition[GO:0071300]  
1
  • Ortholog Curator
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • UniProtKB
Cervix developmentdefinition[GO:0060067] silver  
1
  • Ortholog Compara
Cochlea morphogenesisdefinition[GO:0090103] silver  
1
  • Ortholog Compara
Convergent extension involved in organogenesisdefinition[GO:0060029] silver  
1
  • Ortholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542] silver  
1
  • Ortholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
1
  • Ortholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706]  
1
  • BHF-UCL
Epithelial cell proliferation involved in mammary gland duct elongationdefinition[GO:0060750] silver  
1
  • Ortholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • UniProtKB
Establishment of planar polaritydefinition[GO:0001736] silver  
1
  • Ortholog Compara
Face developmentdefinition[GO:0060324]  
1
  • BHF-UCL
Genitalia developmentdefinition[GO:0048806]  
1
  • BHF-UCL
Heart loopingdefinition[GO:0001947] silver  
1
  • Ortholog Compara
Hematopoietic stem cell proliferationdefinition[GO:0071425]  
1
  • BHF-UCL
Hindgut morphogenesisdefinition[GO:0007442] silver  
1
  • Ortholog Compara
Hypophysis morphogenesisdefinition[GO:0048850] silver  
1
  • Ortholog Compara
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • BHF-UCL
Lateral sprouting involved in mammary gland duct morphogenesisdefinition[GO:0060599] silver  
1
  • Ortholog Compara
Lens development in camera-type eyedefinition[GO:0002088]  
1
  • BHF-UCL
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • UniProtKB
Mammary gland branching involved in thelarchedefinition[GO:0060744] silver  
1
  • Ortholog Compara
Mesenchymal-epithelial cell signalingdefinition[GO:0060638] silver  
1
  • Ortholog Compara
Midgut developmentdefinition[GO:0007494] silver  
1
  • Ortholog Compara
Negative chemotaxisdefinition[GO:0050919] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of axon extension involved in axon guidancedefinition[GO:0048843] silver  
1
  • Ortholog Compara
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
1
  • Ortholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
2
  • UniProtKB
  • MGI
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • BHF-UCL
Negative regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040037] silver  
1
  • Ortholog Compara
Negative regulation of mesenchymal cell proliferationdefinition[GO:0072201]  
1
  • UniProtKB
Negative regulation of prostatic bud formationdefinition[GO:0060686] silver  
1
  • Ortholog Compara
Negative regulation of synapse assemblydefinition[GO:0051964] silver  
1
  • Ortholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • UniProtKB
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182]  
2
  • RefGenome
  • Ortholog Curator
Non-canonical Wnt signaling pathway via JNK cascadedefinition[GO:0038031] silver  
1
  • Ortholog Compara
Olfactory bulb interneuron developmentdefinition[GO:0021891]  
1
  • Ortholog Curator
Optic cup formation involved in camera-type eye developmentdefinition[GO:0003408]  
1
  • BHF-UCL
Palate developmentdefinition[GO:0060021]  
1
  • BHF-UCL
Planar cell polarity pathway involved in cardiac muscle tissue morphogenesisdefinition[GO:0061350] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in cardiac right atrium morphogenesisdefinition[GO:0061349] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in outflow tract morphogenesisdefinition[GO:0061347] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in pericardium morphogenesisdefinition[GO:0061354] silver  
1
  • Ortholog Compara
Planar cell polarity pathway involved in ventricular septum morphogenesisdefinition[GO:0061348] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Positive regulation of cartilage developmentdefinition[GO:0061036] silver  
1
  • Ortholog Compara
Positive regulation of cell-cell adhesion mediated by cadherindefinition[GO:2000049] silver  
1
  • Ortholog Compara
Positive regulation of cGMP metabolic processdefinition[GO:0030825]  
1
  • BHF-UCL
Positive regulation of chemokine biosynthetic processdefinition[GO:0045080]  
1
  • UniProtKB
Positive regulation of cytokine secretion involved in immune responsedefinition[GO:0002741]  
1
  • UniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
2
  • UniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • UniProtKB
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • UniProtKB
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • BHF-UCL
Positive regulation of interferon-gamma productiondefinition[GO:0032729] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-1 beta secretiondefinition[GO:0050718]  
1
  • BHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • BHF-UCL
Positive regulation of interleukin-8 secretiondefinition[GO:2000484] silver  
1
  • Ortholog Compara
Positive regulation of macrophage activationdefinition[GO:0043032]  
1
  • BHF-UCL
Positive regulation of macrophage cytokine productiondefinition[GO:0060907]  
1
  • UniProtKB
Positive regulation of meiosisdefinition[GO:0045836] silver  
1
  • Ortholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
1
  • Ortholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
1
  • Ortholog Curator
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • UniProtKB
Positive regulation of ossificationdefinition[GO:0045778]  
1
  • BHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-threonine phosphorylationdefinition[GO:0010800] silver  
1
  • Ortholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732]  
1
  • MGI
Positive regulation of protein kinase C signalingdefinition[GO:0090037]  
1
  • UniProtKB
Positive regulation of response to cytokine stimulusdefinition[GO:0060760]  
1
  • UniProtKB
Positive regulation of T cell chemotaxisdefinition[GO:0010820]  
1
  • UniProtKB
Positive regulation of thymocyte apoptotic processdefinition[GO:0070245] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Positive regulation of type I interferon-mediated signaling pathwaydefinition[GO:0060340]  
1
  • BHF-UCL
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
1
  • Ortholog Compara
Primitive streak formationdefinition[GO:0090009] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Regulation of branching involved in mammary gland duct morphogenesisdefinition[GO:0060762] silver  
1
  • Ortholog Compara
Response to organic substancedefinition[GO:0010033]  
1
  • UniProtKB
Somitogenesisdefinition[GO:0001756] silver  
1
  • Ortholog Compara
Type B pancreatic cell developmentdefinition[GO:0003323] silver  
1
  • Ortholog Compara
Urinary bladder developmentdefinition[GO:0060157] silver  
1
  • Ortholog Compara
Uterus developmentdefinition[GO:0060065] silver  
1
  • Ortholog Compara
Vagina developmentdefinition[GO:0060068] silver  
1
  • Ortholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • BHF-UCL
Wnt signaling pathway, calcium modulating pathwaydefinition[GO:0007223]  
2
  • BHF-UCL
  • UniProtKB
Wound healingdefinition[GO:0042060]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7474  
Hedgehog signaling pathway  hsa04340+7474  
HTLV-I infection  hsa05166+7474  
Melanogenesis  hsa04916+7474  
Pathways in cancer  hsa05200+7474  
Wnt signaling pathway  hsa04310+7474  
According to Reactome, this protein belongs to the following pathways:
Asymmetric localization of PCP proteins  REACT_172638  
Ca2+ pathway  REACT_172761  
Class B/2 (Secretin family receptors)  REACT_18372  
negative regulation of TCF-dependent signaling by WNT ligand antagonists  REACT_200643  
PCP/CE pathway  REACT_172581  
TCF dependent signaling in response to WNT  REACT_200777  
WNT ligand biogenesis and trafficking  REACT_163710  
WNT5A-dependent internalization of FZD2, FZD5 and ROR2  REACT_172631  
WNT5A-dependent internalization of FZD4  REACT_172599  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WNT5A
GenomeRNAi: 7474
PRO: PR:P41221