WNT5A - Protein Wnt-5a - human protein (Function)
 
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WNT5A »  Protein Wnt-5a
 
Gene name:  WNT5A
Family name: Wnt
Entry whose protein(s) existence is based on evidence at protein level
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1 170 2
GENE REF ISO

Function

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Overview 
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.  
2
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125] silver  
  • IEAOrtholog Compara
Frizzled bindingdefinition[GO:0005109]  
1
  • IPIUniProtKB
Frizzled-2 bindingdefinition[GO:0005110] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Receptor agonist activitydefinition[GO:0048018]  
1
  • ICBHF-UCL
Receptor tyrosine kinase-like orphan receptor bindingdefinition[GO:0005115]  
1
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IMPUniProtKB
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Activation of JUN kinase activitydefinition[GO:0007257]  
2
  • IMPBHF-UCL
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IDABHF-UCL
Activation of protein kinase B activitydefinition[GO:0032148]  
1
  • IDABHF-UCL
Ameboidal cell migrationdefinition[GO:0001667] silver  
  • IEAOrtholog Compara
Anterior/posterior axis specification, embryodefinition[GO:0008595] silver  
  • IEAOrtholog Compara
Axon guidancedefinition[GO:0007411]  
  • ISSOrtholog Curator
Canonical Wnt signaling pathwaydefinition[GO:0060070] silver  
  • IEAOrtholog Compara
Cartilage developmentdefinition[GO:0051216]  
  • IEAUniProtKB KW
Cell fate commitmentdefinition[GO:0045165] silver  
  • IBARefGenome
Cellular protein localizationdefinition[GO:0034613]  
1
  • IDAUniProtKB
Cellular response to calcium iondefinition[GO:0071277]  
1
  • IEPUniProtKB
Cellular response to interferon-gammadefinition[GO:0071346]  
1
  • IEPUniProtKB
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IEPUniProtKB
Cellular response to retinoic aciddefinition[GO:0071300]  
  • ISSOrtholog Curator
Cellular response to transforming growth factor beta stimulusdefinition[GO:0071560]  
1
  • IEPUniProtKB
Cervix developmentdefinition[GO:0060067] silver  
  • IEAOrtholog Compara
Cochlea morphogenesisdefinition[GO:0090103] silver  
  • IEAOrtholog Compara
Convergent extension involved in organogenesisdefinition[GO:0060029] silver  
  • IEAOrtholog Compara
Dopaminergic neuron differentiationdefinition[GO:0071542] silver  
  • IEAOrtholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Embryonic skeletal system developmentdefinition[GO:0048706]  
1
  • IMPBHF-UCL
Epithelial cell proliferation involved in mammary gland duct elongationdefinition[GO:0060750] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • IEPUniProtKB
Establishment of planar polaritydefinition[GO:0001736] silver  
  • IEAOrtholog Compara
Face developmentdefinition[GO:0060324]  
1
  • IMPBHF-UCL
Genitalia developmentdefinition[GO:0048806]  
1
  • IMPBHF-UCL
Heart loopingdefinition[GO:0001947] silver  
  • IEAOrtholog Compara
Hematopoietic stem cell proliferationdefinition[GO:0071425]  
1
  • IDABHF-UCL
Hindgut morphogenesisdefinition[GO:0007442] silver  
  • IEAOrtholog Compara
Hypophysis morphogenesisdefinition[GO:0048850] silver  
  • IEAOrtholog Compara
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • IEPBHF-UCL
Lateral sprouting involved in mammary gland duct morphogenesisdefinition[GO:0060599] silver  
  • IEAOrtholog Compara
Lens development in camera-type eyedefinition[GO:0002088]  
1
  • ISSBHF-UCL
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584]  
1
  • IEPUniProtKB
Mammary gland branching involved in thelarchedefinition[GO:0060744] silver  
  • IEAOrtholog Compara
Mesenchymal-epithelial cell signalingdefinition[GO:0060638] silver  
  • IEAOrtholog Compara
Midgut developmentdefinition[GO:0007494] silver  
  • IEAOrtholog Compara
Negative chemotaxisdefinition[GO:0050919] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • IDAUniProtKB
Negative regulation of axon extension involved in axon guidancedefinition[GO:0048843] silver  
  • IEAOrtholog Compara
Negative regulation of BMP signaling pathwaydefinition[GO:0030514] silver  
  • IEAOrtholog Compara
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
2
  • IDAUniProtKB
  • IGIMGI
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • IMPBHF-UCL
Negative regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040037] silver  
  • IEAOrtholog Compara
Negative regulation of mesenchymal cell proliferationdefinition[GO:0072201]  
1
  • IDAUniProtKB
Negative regulation of prostatic bud formationdefinition[GO:0060686] silver  
  • IEAOrtholog Compara
Negative regulation of synapse assemblydefinition[GO:0051964] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182]  
  • ISSOrtholog Curator
  • IBARefGenome
Non-canonical Wnt signaling pathway via JNK cascadedefinition[GO:0038031] silver  
  • IEAOrtholog Compara
Olfactory bulb interneuron developmentdefinition[GO:0021891]  
  • ISSOrtholog Curator
Optic cup formation involved in camera-type eye developmentdefinition[GO:0003408]  
1
  • ISSBHF-UCL
Palate developmentdefinition[GO:0060021]  
1
  • IMPBHF-UCL
Planar cell polarity pathway involved in cardiac muscle tissue morphogenesisdefinition[GO:0061350] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in cardiac right atrium morphogenesisdefinition[GO:0061349] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in neural tube closuredefinition[GO:0090179] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in outflow tract morphogenesisdefinition[GO:0061347] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in pericardium morphogenesisdefinition[GO:0061354] silver  
  • IEAOrtholog Compara
Planar cell polarity pathway involved in ventricular septum morphogenesisdefinition[GO:0061348] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IMPUniProtKB
Positive regulation of cartilage developmentdefinition[GO:0061036] silver  
  • IEAOrtholog Compara
Positive regulation of cell-cell adhesion mediated by cadherindefinition[GO:2000049] silver  
  • IEAOrtholog Compara
Positive regulation of cGMP metabolic processdefinition[GO:0030825]  
1
  • IDABHF-UCL
Positive regulation of chemokine biosynthetic processdefinition[GO:0045080]  
1
  • IMPUniProtKB
Positive regulation of cytokine secretion involved in immune responsedefinition[GO:0002741]  
1
  • IMPUniProtKB
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
2
  • IMPUniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IMPUniProtKB
Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • IDAUniProtKB
Positive regulation of inflammatory responsedefinition[GO:0050729]  
1
  • IMPBHF-UCL
Positive regulation of interferon-gamma productiondefinition[GO:0032729] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-1 beta secretiondefinition[GO:0050718]  
1
  • IMPBHF-UCL
Positive regulation of interleukin-6 productiondefinition[GO:0032755]  
1
  • IMPBHF-UCL
Positive regulation of interleukin-8 secretiondefinition[GO:2000484] silver  
  • IEAOrtholog Compara
Positive regulation of JNK cascadedefinition[GO:0046330] silver  
  • IEAOrtholog Compara
Positive regulation of macrophage activationdefinition[GO:0043032]  
1
  • IMPBHF-UCL
Positive regulation of macrophage cytokine productiondefinition[GO:0060907]  
1
  • IMPUniProtKB
Positive regulation of meiosisdefinition[GO:0045836] silver  
  • IEAOrtholog Compara
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IEAOrtholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
  • ISSOrtholog Curator
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDAUniProtKB
Positive regulation of ossificationdefinition[GO:0045778]  
1
  • IMPBHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-threonine phosphorylationdefinition[GO:0010800] silver  
  • IEAOrtholog Compara
Positive regulation of protein catabolic processdefinition[GO:0045732]  
1
  • IGIMGI
Positive regulation of protein kinase C signalingdefinition[GO:0090037]  
1
  • IMPUniProtKB
Positive regulation of response to cytokine stimulusdefinition[GO:0060760]  
1
  • IDAUniProtKB
Positive regulation of T cell chemotaxisdefinition[GO:0010820]  
1
  • IMPUniProtKB
Positive regulation of thymocyte apoptotic processdefinition[GO:0070245] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IMPBHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Positive regulation of type I interferon-mediated signaling pathwaydefinition[GO:0060340]  
1
  • IDABHF-UCL
Post-anal tail morphogenesisdefinition[GO:0036342] silver  
  • IEAOrtholog Compara
Primitive streak formationdefinition[GO:0090009] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Regulation of branching involved in mammary gland duct morphogenesisdefinition[GO:0060762] silver  
  • IEAOrtholog Compara
Response to organic substancedefinition[GO:0010033]  
1
  • IEPUniProtKB
Somitogenesisdefinition[GO:0001756] silver  
  • IEAOrtholog Compara
Type B pancreatic cell developmentdefinition[GO:0003323] silver  
  • IEAOrtholog Compara
Urinary bladder developmentdefinition[GO:0060157] silver  
  • IEAOrtholog Compara
Uterus developmentdefinition[GO:0060065] silver  
  • IEAOrtholog Compara
Vagina developmentdefinition[GO:0060068] silver  
  • IEAOrtholog Compara
Wnt signaling pathwaydefinition[GO:0016055]  
1
  • IDABHF-UCL
Wnt signaling pathway, calcium modulating pathwaydefinition[GO:0007223]  
2
  • IDABHF-UCL
  • IMPUniProtKB
Wound healingdefinition[GO:0042060]  
1
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7474  
Hedgehog signaling pathway  hsa04340+7474  
HTLV-I infection  hsa05166+7474  
Melanogenesis  hsa04916+7474  
Pathways in cancer  hsa05200+7474  
Wnt signaling pathway  hsa04310+7474  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: WNT5A
GenomeRNAi: 7474
PRO: PR:P41221