SOX3 - Transcription factor SOX-3 - human protein (Function)
 
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SOX3 »  Transcription factor SOX-3
 
Gene name:  SOX3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).  
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  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
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  • PINC
RNA polymerase II core promoter sequence-specific DNA bindingdefinition[GO:0000979]  
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  • Ortholog Curator
RNA polymerase II transcription corepressor activitydefinition[GO:0001106]  
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  • Ortholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
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  • InterPro 2 GO
GO biological process 
Central nervous system developmentdefinition[GO:0007417]  
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  • PINC
Face developmentdefinition[GO:0060324]  
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  • Ortholog Curator
Hypothalamus developmentdefinition[GO:0021854]  
1
  • Ortholog Curator
Negative regulation of neuron differentiationdefinition[GO:0045665]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
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  • Ortholog Compara
Neuron developmentdefinition[GO:0048666] silver  
1
  • InterPro 2 GO
Organ morphogenesisdefinition[GO:0009887] silver  
1
  • Ortholog Compara
Pituitary gland developmentdefinition[GO:0021983]  
1
  • Ortholog Curator
Sensory organ developmentdefinition[GO:0007423]  
1
  • Ortholog Curator
Sertoli cell developmentdefinition[GO:0060009] silver  
1
  • Ortholog Compara
Sex determinationdefinition[GO:0007530]  
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  • UniProtKB
Spermatid differentiationdefinition[GO:0048515] silver  
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  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
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  • UniProtKB KW
Caution 
Was originally termed SOX-9.  
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  • UniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SOX3
GenomeRNAi: 6658
PRO: PR:P41225