P2RY2 - P2Y purinoceptor 2 - human protein (Function)
 
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P2RY2 »  P2Y purinoceptor 2  (P2Y2)
 
Protein also known as:  Purinergic receptor.
Gene name:  P2RY2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.  
1
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
1
  • Ortholog Compara
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028] silver  
1
  • InterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • PINC
UTP-activated nucleotide receptor activitydefinition[GO:0045030] silver  
1
  • Ortholog Compara
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Cellular ion homeostasisdefinition[GO:0006873]  
1
  • PINC
Cellular response to interleukin-1definition[GO:0071347] silver  
1
  • Ortholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222] silver  
1
  • Ortholog Compara
Cellular response to purine-containing compounddefinition[GO:0071415] silver  
1
  • Ortholog Compara
G-protein coupled purinergic nucleotide receptor signaling pathwaydefinition[GO:0035589]  
1
  • InterPro 2 GO
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Negative regulation of ossificationdefinition[GO:0030279] silver  
1
  • Ortholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
1
  • InterPro 2 GO
Positive regulation of chemokine productiondefinition[GO:0032722] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Positive regulation of mucus secretiondefinition[GO:0070257] silver  
1
  • InterPro 2 GO
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
1
  • Ortholog Compara
Positive regulation of penile erectiondefinition[GO:0060406] silver  
1
  • Ortholog Compara
Positive regulation of prostaglandin secretiondefinition[GO:0032308] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911] silver  
1
  • Ortholog Compara
Regulation of vasodilationdefinition[GO:0042312] silver  
1
  • Ortholog Compara
Response to growth factordefinition[GO:0070848] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+5029  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  R-HSA-416476  
P2Y receptors  R-HSA-417957  
Surfactant metabolism  R-HSA-5683826  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY2
GenomeRNAi: 5029
PRO: PR:P41231
Chemistry
GuidetoPHARMACOLOGY: 324