P2RY2 - P2Y purinoceptor 2 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
P2RY2 »  P2Y purinoceptor 2  (P2Y2)
 
Protein also known as:  Purinergic receptor.
Gene name:  P2RY2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 77 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028] silver  
  • IEAInterPro 2 GO
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
GO biological process 
Cellular ion homeostasisdefinition[GO:0006873]  
1
  • TASPINC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAInterPro 2 GO
Positive regulation of mucus secretiondefinition[GO:0070257] silver  
  • IEAOrtholog Compara
Regulation of vasodilationdefinition[GO:0042312] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+5029  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY2
GenomeRNAi: 5029
PRO: PR:P41231
Chemistry
GuidetoPHARMACOLOGY: 324