HNF4A - Hepatocyte nuclear factor 4-alpha - human protein (Function)
 
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HNF4A »  Hepatocyte nuclear factor 4-alpha  (HNF-4-alpha)
 
Protein also known as:  Nuclear receptor subfamily 2 group A member 1.
Gene name:  HNF4A
Family name: Nuclear hormone receptor » NR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
2
  • IDABHF-UCL
  • IDAMGI
Fatty acid bindingdefinition[GO:0005504]  
1
  • IDABHF-UCL
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • IDABHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
  • ISSOrtholog Curator
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
  • ISSOrtholog Curator
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
  • IEAOrtholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
4
  • IDABHF-UCL
  • IDAMGI
Steroid hormone receptor activitydefinition[GO:0003707] silver  
  • IEAInterPro 2 GO
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Blood coagulationdefinition[GO:0007596]  
1
  • IDABHF-UCL
Glucose homeostasisdefinition[GO:0042593]  
  • ISSOrtholog Curator
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
  • IEAInterPro 2 GO
Lipid homeostasisdefinition[GO:0055088]  
1
  • IMPBHF-UCL
Lipid metabolic processdefinition[GO:0006629] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPBHF-UCL
Ornithine metabolic processdefinition[GO:0006591]  
1
  • IMPBHF-UCL
Phospholipid homeostasisdefinition[GO:0055091]  
  • ISSOrtholog Curator
Positive regulation of cholesterol homeostasisdefinition[GO:2000189]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IMPBHF-UCL
  • IDAMGI
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Regulation of gastrulationdefinition[GO:0010470] silver  
  • IEAOrtholog Compara
Isoforms  HNF4-Alpha-2 and HNF4-Alpha-8   Regulation of growth hormone receptor signaling pathwaydefinition[GO:0060398]  
1
  • NASBHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
  • ISSOrtholog Curator
Regulation of lipid metabolic processdefinition[GO:0019216]  
1
  • IDABHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
3
  • IMPBHF-UCL
Response to glucosedefinition[GO:0009749]  
  • ISSOrtholog Curator
Sex differentiationdefinition[GO:0007548] silver  
  • IEAOrtholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
SMAD protein signal transductiondefinition[GO:0060395] silver  
  • IEAOrtholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
  • IEAInterPro 2 GO
Triglyceride homeostasisdefinition[GO:0070328]  
  • ISSOrtholog Curator
Xenobiotic metabolic processdefinition[GO:0006805]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathway:
Maturity onset diabetes of the young  hsa04950+3172  
According to Reactome, this protein belongs to the following pathways:
Nuclear Receptor transcription pathway  REACT_15525  
Regulation of gene expression in beta cells  REACT_13819  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Hepatocyte_nuclear_factor_4_alpha
GenomeRNAi: 3172
PRO: PR:P41235
Chemistry
GuidetoPHARMACOLOGY: 608