CSK - Tyrosine-protein kinase CSK - human protein (Function)
 
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CSK »  Tyrosine-protein kinase CSK   [ EC 2.7.10.2 ]
 
Protein also known as:  Protein-tyrosine kinase CYL.
Gene name:  CSK
Entry whose protein(s) existence is based on evidence at protein level
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1 130 1
GENE REF ISO

Function

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Overview 
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
  • IEAEC 2 GO
Proline-rich region bindingdefinition[GO:0070064] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
7
  • IPIUniProtKB
  • IPIIntAct
  • IPIHGNC
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • TASPINC
Protein phosphatase bindingdefinition[GO:0019903] silver  
  • IEAOrtholog Compara
GO biological process 
Adherens junction organizationdefinition[GO:0034332] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
  • IEAOrtholog Compara
Negative regulation of bone resorptiondefinition[GO:0045779] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373] silver  
  • IEAOrtholog Compara
Negative regulation of Golgi to plasma membrane protein transportdefinition[GO:0042997]  
1
  • IDAUniProtKB
Negative regulation of interleukin-6 productiondefinition[GO:0032715] silver  
  • IEAOrtholog Compara
Negative regulation of kinase activitydefinition[GO:0033673] silver  
  • IEAOrtholog Compara
Negative regulation of low-density lipoprotein particle clearancedefinition[GO:0010989] silver  
  • IEAOrtholog Compara
Negative regulation of phagocytosisdefinition[GO:0050765] silver  
  • IEAOrtholog Compara
Oligodendrocyte differentiationdefinition[GO:0048709] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • TASGOC
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of Fc receptor mediated stimulatory signaling pathwaydefinition[GO:0060368] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+1445  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Hemostasis  REACT_604  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C-src_tyrosine_kinase
GenomeRNAi: 1445
PRO: PR:P41240
Chemistry
GuidetoPHARMACOLOGY: 1994