CSK - Tyrosine-protein kinase CSK - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CSK »  Tyrosine-protein kinase CSK   [ EC 2.7.10.2 ]
 
Protein also known as:  Protein-tyrosine kinase CYL.
Gene name:  CSK
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 136 1
GENE REF ISO

Function

 show evidences
Overview 
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • RefGenome
Proline-rich region bindingdefinition[GO:0070064] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
7
  • UniProtKB
  • IntAct
  • HGNC
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • PINC
Protein phosphatase bindingdefinition[GO:0019903] silver  
1
  • Ortholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • RefGenome
GO biological process 
Adherens junction organizationdefinition[GO:0034332]  
1
  • RefGenome
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Cellular response to peptide hormone stimulusdefinition[GO:0071375] silver  
1
  • Ortholog Compara
Central nervous system developmentdefinition[GO:0007417]  
1
  • RefGenome
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Morphogenesis of an epitheliumdefinition[GO:0002009]  
1
  • RefGenome
Negative regulation of bone resorptiondefinition[GO:0045779] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373] silver  
1
  • Ortholog Compara
Negative regulation of Golgi to plasma membrane protein transportdefinition[GO:0042997]  
1
  • UniProtKB
Negative regulation of interleukin-6 productiondefinition[GO:0032715] silver  
1
  • Ortholog Compara
Negative regulation of kinase activitydefinition[GO:0033673] silver  
1
  • Ortholog Compara
Negative regulation of low-density lipoprotein particle clearancedefinition[GO:0010989] silver  
1
  • Ortholog Compara
Negative regulation of phagocytosisdefinition[GO:0050765] silver  
1
  • Ortholog Compara
Oligodendrocyte differentiationdefinition[GO:0048709] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Regulation of cytokine productiondefinition[GO:0001817]  
1
  • RefGenome
Regulation of Fc receptor mediated stimulatory signaling pathwaydefinition[GO:0060368]  
1
  • RefGenome
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Epithelial cell signaling in Helicobacter pylori infection  hsa05120+1445  
According to Reactome, this protein belongs to the following pathways:
GAB1 signalosome  REACT_12578  
Integrin alphaIIb beta3 signaling  REACT_15523  
PD-1 signaling  REACT_19324  
Phosphorylation of CD3 and TCR zeta chains  REACT_12582  
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C-src_tyrosine_kinase
GenomeRNAi: 1445
PRO: PR:P41240
Chemistry
GuidetoPHARMACOLOGY: 1994