GARS - Glycine--tRNA ligase - human protein (Function)
 
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Protein
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References

 
GARS »  Glycine--tRNA ligase   [ EC 6.1.1.14 ]
 
Protein also known as:  Diadenosine tetraphosphate synthetase (AP-4-A synthetase).
Gene name:  GARS
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Glycine-tRNA ligase activitydefinition[GO:0004820]  
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  • IDAUniProtKB
Protein dimerization activitydefinition[GO:0046983]  
2
  • IDAUniProtKB
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Diadenosine tetraphosphate biosynthetic processdefinition[GO:0015966]  
1
  • IDAUniProtKB
Glycyl-tRNA aminoacylationdefinition[GO:0006426] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.1.1.14: ATP + glycine + tRNA(Gly) AMP + diphosphate + glycyl-tRNA(Gly).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aminoacyl-tRNA biosynthesis  hsa00970+2617  
According to Reactome, this protein belongs to the following pathway:
Gene Expression  REACT_71  
 

Biophysicochemical properties

Kinetic parameters
KM 1.3 uM for tRNA(Gly(GCC))
KM 15 uM for glycine

Keywords

Biological process 
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Aminoacyl-tRNA synthetase  definition   [KW-0030]
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links