ADCYAP1R1 - Pituitary adenylate cyclase-activating polypeptide type I receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ADCYAP1R1 »  Pituitary adenylate cyclase-activating polypeptide type I receptor  (PACAP-R1)
 
Gene name:  ADCYAP1R1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 62 5
GENE REF ISO

Function

 show evidences
Overview 
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.8  
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • PINC
Vasoactive intestinal polypeptide receptor activitydefinition[GO:0004999] silver  
1
  • InterPro 2 GO
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • UniProtKB KW
Spermatogenesisdefinition[GO:0007283]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+117  
According to Reactome, this protein belongs to the following pathways:
G alpha (s) signalling events  REACT_19327  
Glucagon-type ligand receptors  REACT_18377  
NGF-independant TRKA activation  REACT_11046  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADCYAP1R1
GenomeRNAi: 117
PRO: PR:P41586
Chemistry
GuidetoPHARMACOLOGY: 370