ADCYAP1R1 - Pituitary adenylate cyclase-activating polypeptide type I receptor - human protein (Function)
 
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ADCYAP1R1 »  Pituitary adenylate cyclase-activating polypeptide type I receptor  (PACAP-R1)
 
Gene name:  ADCYAP1R1
Entry whose protein(s) existence is based on evidence at protein level
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1 54 5
GENE REF ISO

Function

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Overview 
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.8  
GO molecular function 
Adenylate cyclase bindingdefinition[GO:0008179] silver  
  • IEAOrtholog Compara
ADP-ribosylation factor bindingdefinition[GO:0030306] silver  
  • IEAOrtholog Compara
Neuropeptide bindingdefinition[GO:0042923] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Vasoactive intestinal polypeptide receptor activitydefinition[GO:0004999] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202] silver  
  • IEAOrtholog Compara
cAMP-mediated signalingdefinition[GO:0019933] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Development of primary female sexual characteristicsdefinition[GO:0046545] silver  
  • IEAOrtholog Compara
Multicellular organismal response to stressdefinition[GO:0033555] silver  
  • IEAOrtholog Compara
Negative regulation of cell deathdefinition[GO:0060548] silver  
  • IEAOrtholog Compara
Positive regulation of calcium ion transport into cytosoldefinition[GO:0010524] silver  
  • IEAOrtholog Compara
Positive regulation of inositol phosphate biosynthetic processdefinition[GO:0060732] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to estradioldefinition[GO:0032355] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+117  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Spermatogenesis  definition   [KW-0744]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ADCYAP1R1
GenomeRNAi: 117
PRO: PR:P41586
Chemistry
GuidetoPHARMACOLOGY: 370